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DOI | 10.1126/science.aav9051 |
3D bioprinting of collagen to rebuild components of the human heart | |
Lee, A.1; Hudson, A. R.1; Shiwarski, D. J.1; Tashman, J. W.1; Hinton, T. J.1; Yerneni, S.1; Bliley, J. M.1; Campbell, P. G.1,2; Feinberg, A. W.1,3 | |
2019-08-02 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6452页码:482-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Collagen is the primary component of the extracellular matrix in the human body. It has proved challenging to fabricate collagen scaffolds capable of replicating the structure and function of tissues and organs. We present a method to 3D-bioprint collagen using freeform reversible embedding of suspended hydrogels (FRESH) to engineer components of the human heart at various scales, from capillaries to the full organ. Control of pH-driven gelation provides 20-micrometer filament resolution, a porous microstructure that enables rapid cellular infiltration and microvascularization, and mechanical strength for fabrication and perfusion of multiscale vasculature and tri-leaflet valves. We found that FRESH 3D-bioprinted hearts accurately reproduce patient-specific anatomical structure as determined by micro-computed tomography. Cardiac ventricles printed with human cardiomyocytes showed synchronized contractions, directional action potential propagation, and wall thickening up to 14% during peak systole. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000485768400044 |
WOS关键词 | VASCULAR NETWORKS ; VALVE CONDUITS ; GENERATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201999 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Carnegie Mellon Univ, Dept Biomed Engn, Pittsburgh, PA 15213 USA; 2.Carnegie Mellon Univ, Engn Res Accelerator, Pittsburgh, PA 15213 USA; 3.Carnegie Mellon Univ, Dept Mat Sci & Engn, Pittsburgh, PA 15213 USA |
推荐引用方式 GB/T 7714 | Lee, A.,Hudson, A. R.,Shiwarski, D. J.,et al. 3D bioprinting of collagen to rebuild components of the human heart[J]. SCIENCE,2019,365(6452):482-+. |
APA | Lee, A..,Hudson, A. R..,Shiwarski, D. J..,Tashman, J. W..,Hinton, T. J..,...&Feinberg, A. W..(2019).3D bioprinting of collagen to rebuild components of the human heart.SCIENCE,365(6452),482-+. |
MLA | Lee, A.,et al."3D bioprinting of collagen to rebuild components of the human heart".SCIENCE 365.6452(2019):482-+. |
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