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DOI | 10.1126/science.aaw1720 |
Isochorismate-derived biosynthesis of the plant stress hormone salicylic acid | |
Rekhter, Dmitrij1; Luedke, Daniel2; Ding, Yuli3; Feussner, Kirstin1,4; Zienkiewicz, Krzysztof1; Lipka, Volker5,6; Wiermer, Marcel2; Zhang, Yuelin3; Feussner, Ivo1,7 | |
2019-08-02 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6452页码:498-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; Canada |
英文摘要 | The phytohormone salicylic acid (SA) controls biotic and abiotic plant stress responses. Plastid-produced chorismate is a branch-point metabolite for SA biosynthesis. Most pathogen-induced SA derives from isochorismate, which is generated from chorismate by the catalytic activity of ISOCHORISMATE SYNTHASE1. Here, we ask how and in which cellular compartment isochorismate is converted to SA. We show that in Arabidopsis, the pathway downstream of isochorismate requires only two additional proteins: ENHANCED DISEASE SUSCEPTIBILITY5, which exports isochorismate from the plastid to the cytosol, and the cytosolic amidotransferase avrPphB SUSCEPTIBLE3 (PBS3). PBS3 catalyzes the conjugation of glutamate to isochorismate to produce isochorismate-9-glutamate, which spontaneously decomposes into SA and 2-hydroxy-acryloyl-N-glutamate. The minimal requirement of three compartmentalized proteins controlling unidirectional forward flux may protect the pathway against evolutionary forces and pathogen perturbations. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000485768400048 |
WOS关键词 | DISEASE RESISTANCE ; DEFENSE RESPONSES ; ARABIDOPSIS ; PERCEPTION ; SYNTHASE ; PROTEIN ; MEMBER ; GENES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201998 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Goettingen, Albrecht von Haller Inst Plant Sci, Dept Plant Biochem, D-37077 Gottingen, Germany; 2.Univ Goettingen, Albrecht von Haller Inst Plant Sci, Mol Biol Plant Microbe Interact Res Grp, D-37077 Gottingen, Germany; 3.Univ British Columbia, Dept Bot, Vancouver, BC V6T 1Z4, Canada; 4.Univ Goettingen, Goettingen Ctr Mol Biosci GZMB, Serv Unit Metabol & Lipid, D-37077 Gottingen, Germany; 5.Univ Goettingen, Albrecht von Haller Inst Plant Sci, Dept Plant Cell Biol, D-37077 Gottingen, Germany; 6.Univ Goettingen, Fac Biol & Psychol, Cent Microscopy Facil, D-37077 Gottingen, Germany; 7.Univ Goettingen, Dept Plant Biochem, Goettingen Ctr Mol Biosci GZMB, D-37077 Gottingen, Germany |
推荐引用方式 GB/T 7714 | Rekhter, Dmitrij,Luedke, Daniel,Ding, Yuli,et al. Isochorismate-derived biosynthesis of the plant stress hormone salicylic acid[J]. SCIENCE,2019,365(6452):498-+. |
APA | Rekhter, Dmitrij.,Luedke, Daniel.,Ding, Yuli.,Feussner, Kirstin.,Zienkiewicz, Krzysztof.,...&Feussner, Ivo.(2019).Isochorismate-derived biosynthesis of the plant stress hormone salicylic acid.SCIENCE,365(6452),498-+. |
MLA | Rekhter, Dmitrij,et al."Isochorismate-derived biosynthesis of the plant stress hormone salicylic acid".SCIENCE 365.6452(2019):498-+. |
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