Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aav9314 |
Stem cell differentiation trajectories in Hydra resolved at single-cell resolution | |
Siebert, Stefan1; Farrell, Jeffrey A.2; Cazet, Jack F.1; Abeykoon, Yashodara1; Primack, Abby S.1; Schnitzler, Christine E.3,4; Juliano, Celina E.1 | |
2019-07-26 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6451页码:341-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | The adult Hydra polyp continually renews all of its cells using three separate stem cell populations, but the genetic pathways enabling this homeostatic tissue maintenance are not well understood. We sequenced 24,985 Hydra single-cell transcriptomes and identified the molecular signatures of a broad spectrum of cell states, from stem cells to terminally differentiated cells. We constructed differentiation trajectories for each cell lineage and identified gene modules and putative regulators expressed along these trajectories, thus creating a comprehensive molecular map of all developmental lineages in the adult animal. In addition, we built a gene expression map of the Hydra nervous system. Our work constitutes a resource for addressing questions regarding the evolution of metazoan developmental processes and nervous system function. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000477703100032 |
WOS关键词 | GENE-EXPRESSION ; NERVOUS-SYSTEM ; METAZOAN HYDRA ; AXIS FORMATION ; HEAD FORMATION ; PIWI PROTEINS ; GLAND-CELLS ; EVOLUTIONARY ; MECHANISMS ; BASAL |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201949 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Calif Davis, Dept Mol & Cellular Biol, Davis, CA 95616 USA; 2.Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA; 3.Univ Florida, Whitney Lab Marine Biosci, St Augustine, FL USA; 4.Univ Florida, Dept Biol, St Augustine, FL USA |
推荐引用方式 GB/T 7714 | Siebert, Stefan,Farrell, Jeffrey A.,Cazet, Jack F.,et al. Stem cell differentiation trajectories in Hydra resolved at single-cell resolution[J]. SCIENCE,2019,365(6451):341-+. |
APA | Siebert, Stefan.,Farrell, Jeffrey A..,Cazet, Jack F..,Abeykoon, Yashodara.,Primack, Abby S..,...&Juliano, Celina E..(2019).Stem cell differentiation trajectories in Hydra resolved at single-cell resolution.SCIENCE,365(6451),341-+. |
MLA | Siebert, Stefan,et al."Stem cell differentiation trajectories in Hydra resolved at single-cell resolution".SCIENCE 365.6451(2019):341-+. |
条目包含的文件 | 条目无相关文件。 |
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