Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aaw7317 |
Conservation, acquisition, and functional impact of sex-biased gene expression in mammals | |
Naqvi, Sahin1,2; Godfrey, Alexander K.1,2; Hughes, Jennifer F.1; Goodheart, Mary L.1,3; Mitchell, Richard N.4; Page, David C.1,2,3 | |
2019-07-19 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6450页码:249-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Sex differences abound in human health and disease, as they do in other mammals used as models. The extent to which sex differences are conserved at the molecular level across species and tissues is unknown. We surveyed sex differences in gene expression in human, macaque, mouse, rat, and dog, across 12 tissues. In each tissue, we identified hundreds of genes with conserved sex-biased expression-findings that, combined with genomic analyses of human height, explain similar to 12% of the difference in height between females and males. We surmise that conserved sex biases in expression of genes otherwise operating equivalently in females and males contribute to sex differences in traits. However, most sex-biased expression arose during the mammalian radiation, which suggests that careful attention to interspecies divergence is needed when modeling human sex differences. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000476479200044 |
WOS关键词 | DOSAGE COMPENSATION ; TRANSCRIPTOME ; EVOLUTION ; CHROMOSOME ; GENDER ; SPECTRUM ; REVEALS ; STATURE ; TRAITS ; SIZE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201889 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Whitehead Inst, Cambridge, MA 02142 USA; 2.MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02139 USA; 3.Whitehead Inst, Howard Hughes Med Inst, Cambridge, MA 02142 USA; 4.Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USA |
推荐引用方式 GB/T 7714 | Naqvi, Sahin,Godfrey, Alexander K.,Hughes, Jennifer F.,et al. Conservation, acquisition, and functional impact of sex-biased gene expression in mammals[J]. SCIENCE,2019,365(6450):249-+. |
APA | Naqvi, Sahin,Godfrey, Alexander K.,Hughes, Jennifer F.,Goodheart, Mary L.,Mitchell, Richard N.,&Page, David C..(2019).Conservation, acquisition, and functional impact of sex-biased gene expression in mammals.SCIENCE,365(6450),249-+. |
MLA | Naqvi, Sahin,et al."Conservation, acquisition, and functional impact of sex-biased gene expression in mammals".SCIENCE 365.6450(2019):249-+. |
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