Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aau4732 |
Effects of microbiota-directed foods in gnotobiotic animals and undernourished children | |
Gehrig, Jeanette L.1; 39;Donnell, David2 | |
2019-07-12 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6449页码:139-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; France; Saudi Arabia; Russia; Bangladesh |
英文摘要 | To examine the contributions of impaired gut microbial community development to childhood undernutrition, we combined metabolomic and proteomic analyses of plasma samples with metagenomic analyses of fecal samples to characterize the biological state of Bangladeshi children with severe acute malnutrition (SAM) as they transitioned, after standard treatment, to moderate acute malnutrition (MAM) with persistent microbiota immaturity. Host and microbial effects of microbiota-directed complementary food (MDCF) prototypes targeting weaning-phase bacterial taxa underrepresented in SAM and MAM microbiota were characterized in gnotobiotic mice and gnotobiotic piglets colonized with age-and growth-discriminatory bacteria. A randomized, double-blind controlled feeding study identified a lead MDCF that changes the abundances of targeted bacteria and increases plasma biomarkers and mediators of growth, bone formation, neurodevelopment, and immune function in children with MAM. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000474905400034 |
WOS关键词 | SEVERE ACUTE MALNUTRITION ; IGF-BINDING-PROTEINS ; MAL-ED COHORT ; NF-KAPPA-B ; T-CELLS ; PEPTIDE IDENTIFICATION ; ENDOTHELIAL-CELLS ; DENDRITIC CELLS ; POTENTIAL ROLE ; BONE-FORMATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201850 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Washington Univ, Sch Med, Edison Family Ctr Genome Sci & Syst Biol, St Louis, MO 63110 USA; 2.Washington Univ, Sch Med, Ctr Gut Microbiome & Nutr Res, St Louis, MO 63110 USA; 3.Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA; 4.Washington Univ, Div Comparat Med, St Louis, MO 63110 USA; 5.Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA; 6.CNRS, Architecture & Fonct Macromol Biol, F-13288 Marseille 9, France; 7.Aix Marseille Univ, F-13288 Marseille 9, France; 8.King Abdulaziz Univ, Dept Biol Sci, Jeddah, Saudi Arabia; 9.Oak Ridge Natl Lab, Div Chem Sci, Oak Ridge, TN 37830 USA; 10.Duke Univ, Med Ctr, Sarah W Stedman Nutr & Metab Ctr, Durham, NC 27710 USA; 11.Duke Univ, Med Ctr, Duke Mol Physiol Inst, Durham, NC 27710 USA; 12.Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA; 13.Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA; 14.Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA; 15.Washington Univ, Sch Med, Genome Technol Access Ctr, St Louis, MO 63110 USA; 16.Russian Acad Sci, AA Kharkevich Inst Informat Transmiss Problems, Moscow 127994, Russia; 17.Sanford Burnham Prebys Med Discovery Inst, Infect & Inflammatory Dis Ctr, La Jolla, CA 92037 USA; 18.Int Ctr Diarrhoeal Dis Res, Dhaka 1212, Bangladesh; 19.Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA |
推荐引用方式 GB/T 7714 | Gehrig, Jeanette L.,39;Donnell, David. Effects of microbiota-directed foods in gnotobiotic animals and undernourished children[J]. SCIENCE,2019,365(6449):139-+. |
APA | Gehrig, Jeanette L.,&39;Donnell, David.(2019).Effects of microbiota-directed foods in gnotobiotic animals and undernourished children.SCIENCE,365(6449),139-+. |
MLA | Gehrig, Jeanette L.,et al."Effects of microbiota-directed foods in gnotobiotic animals and undernourished children".SCIENCE 365.6449(2019):139-+. |
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