Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aau4735 |
A sparse covarying unit that describes healthy and impaired human gut microbiota development | |
Raman, Arjun S.1,2; Gehrig, Jeanette L.1,2; Venkatesh, Siddarth1,2; Chang, Hao-Wei1,2; Hibberd, Matthew C.1,2; Subramanian, Sathish1,2,15; Kang, Gagandeep3; Bessong, Pascal O.4; Lima, Aldo A. M.5,6; Kosek, Margaret N.7,8,9; Petri, William A., Jr.9,10,11; Rodionov, Dmitry A.12,13; Arzamasov, Aleksandr A.12,13; Leyn, Semen A.12,13; Osterman, Andrei L.13; Huq, Sayeeda14; Mostafa, Ishita14; Islam, Munirul14; Mahfuz, Mustafa14; Haque, Rashidul14; Ahmed, Tahmeed14; Barratt, Michael J.1,2; Gordon, Jeffrey I.1,2 | |
2019-07-12 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6449页码:140-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; India; South Africa; Brazil; Peru; Russia; Bangladesh |
英文摘要 | Characterizing the organization of the human gut microbiota is a formidable challenge given the number of possible interactions between its components. Using a statistical approach initially applied to financial markets, we measured temporally conserved covariance among bacterial taxa in the microbiota of healthy members of a Bangladeshi birth cohort sampled from I to 60 months of age. The results revealed an "ecogroup" of 15 covarying bacterial taxa that provide a concise description of microbiota development in healthy children from this and other low-income countries, and a means for monitoring community repair in undernourished children treated with therapeutic foods. Features of ecogroup population dynamics were recapitulated in gnotobiotic piglets as they transitioned from exclusive milk feeding to a fully weaned state consuming a representative Bangladeshi diet. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000474905400035 |
WOS关键词 | ANNOTATION ; GROWTH ; AGE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201849 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Washington Univ, Sch Med, Edison Family Ctr Genome Sci & Syst Biol, St Louis, MO 63110 USA; 2.Washington Univ, Sch Med, Ctr Gut Microbiome & Nutr Res, St Louis, MO 63110 USA; 3.Translat Hlth Sci & Technol Inst, Faridabad, Haryana, India; 4.Univ Venda, Dept Microbiol, HIV AIDS & Global Hlth Res Programme, ZA-0950 Thohoyandou, South Africa; 5.Univ Fed Ceara, Sch Med, Clin Res Unit, Ctr Global Hlth,Dept Physiol & Pharmacol, BR-60430270 Fortaleza, Ceara, Brazil; 6.Univ Fed Ceara, Sch Med, Inst Biomed, BR-60430270 Fortaleza, Ceara, Brazil; 7.Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD 21205 USA; 8.AB PRISMA, Ramirez Hurtado 622, Iquitos, Peru; 9.Univ Virginia, Sch Med, Dept Med, Charlottesville, VA 22908 USA; 10.Univ Virginia, Sch Med, Dept Microbiol, Charlottesville, VA 22908 USA; 11.Univ Virginia, Sch Med, Dept Pathol, Charlottesville, VA 22908 USA; 12.Russian Acad Sci, AA Kharkevich Inst Informat Transmiss Problems, Moscow 127994, Russia; 13.Sanford Burnham Prebys Med Discovery Inst, Infect & Inflammatory Dis Ctr, La Jolla, CA 92037 USA; 14.Int Ctr Diarrhoeal Dis Res, Dhaka 1212, Bangladesh; 15.Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA |
推荐引用方式 GB/T 7714 | Raman, Arjun S.,Gehrig, Jeanette L.,Venkatesh, Siddarth,et al. A sparse covarying unit that describes healthy and impaired human gut microbiota development[J]. SCIENCE,2019,365(6449):140-+. |
APA | Raman, Arjun S..,Gehrig, Jeanette L..,Venkatesh, Siddarth.,Chang, Hao-Wei.,Hibberd, Matthew C..,...&Gordon, Jeffrey I..(2019).A sparse covarying unit that describes healthy and impaired human gut microbiota development.SCIENCE,365(6449),140-+. |
MLA | Raman, Arjun S.,et al."A sparse covarying unit that describes healthy and impaired human gut microbiota development".SCIENCE 365.6449(2019):140-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论