GSTDTAP  > 地球科学
DOI10.1126/science.aau9263
A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation
Cui, Yixian1; Parashar, Smriti1; Zahoor, Muhammad2; Needham, Patrick G.3; Mari, Muriel4; Zhu, Ming1; Chen, Shuliang1; Ho, Hsuan-Chung1; Reggiori, Fulvio4; Farhan, Hesso2; Brodsky, Jeffrey L.3; Ferro-Novick, Susan1
2019-07-05
发表期刊SCIENCE
ISSN0036-8075
EISSN1095-9203
出版年2019
卷号365期号:6448页码:53-60
文章类型Article
语种英语
国家USA; Norway; Netherlands
英文摘要

The COPII-cargo adaptor complex Lst1-Sec23 selectively sorts proteins into vesicles that bud from the endoplasmic reticulum (ER) and traffic to the Golgi. Improperly folded proteins are prevented from exiting the ER and are degraded. ER-phagy is an autophagic degradation pathway that uses ER-resident receptors. Working in yeast, we found an unexpected role for Lst1-Sec23 in ER-phagy that was independent from its function in secretion. Up-regulation of the stress-inducible ER-phagy receptor Atg40 induced the association of Lst1-Sec23 with Atg40 at distinct ER domains to package ER into autophagosomes. Lst1-mediated ER-phagy played a vital role in maintaining cellular homeostasis by preventing the accumulation of an aggregationprone protein in the ER. Lst1 function appears to be conserved because its mammalian homolog, SEC24C, was also required for ER-phagy.


领域地球科学 ; 气候变化 ; 资源环境
收录类别SCI-E
WOS记录号WOS:000474432700031
WOS关键词UNFOLDED PROTEIN RESPONSE ; SELECTIVE AUTOPHAGY ; CARGO ; YEAST ; LUNAPARK ; PATHWAYS ; TURNOVER ; TRIGGERS ; REQUIRES ; TEX264
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/201803
专题地球科学
资源环境科学
气候变化
作者单位1.Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USA;
2.Univ Oslo, Inst Basic Med Sci, Dept Mol Med, Sognsvannsveien 9, N-0372 Oslo, Norway;
3.Univ Pittsburgh, Dept Biol Sci, Pittsburgh, PA 15260 USA;
4.Univ Groningen, Dept Biomed Sci Cells & Syst, Med Ctr, Groningen, Netherlands
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Cui, Yixian,Parashar, Smriti,Zahoor, Muhammad,et al. A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation[J]. SCIENCE,2019,365(6448):53-60.
APA Cui, Yixian.,Parashar, Smriti.,Zahoor, Muhammad.,Needham, Patrick G..,Mari, Muriel.,...&Ferro-Novick, Susan.(2019).A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation.SCIENCE,365(6448),53-60.
MLA Cui, Yixian,et al."A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation".SCIENCE 365.6448(2019):53-60.
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