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DOI | 10.1126/science.aau9263 |
A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation | |
Cui, Yixian1; Parashar, Smriti1; Zahoor, Muhammad2; Needham, Patrick G.3; Mari, Muriel4; Zhu, Ming1; Chen, Shuliang1; Ho, Hsuan-Chung1; Reggiori, Fulvio4; Farhan, Hesso2; Brodsky, Jeffrey L.3; Ferro-Novick, Susan1 | |
2019-07-05 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6448页码:53-60 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Norway; Netherlands |
英文摘要 | The COPII-cargo adaptor complex Lst1-Sec23 selectively sorts proteins into vesicles that bud from the endoplasmic reticulum (ER) and traffic to the Golgi. Improperly folded proteins are prevented from exiting the ER and are degraded. ER-phagy is an autophagic degradation pathway that uses ER-resident receptors. Working in yeast, we found an unexpected role for Lst1-Sec23 in ER-phagy that was independent from its function in secretion. Up-regulation of the stress-inducible ER-phagy receptor Atg40 induced the association of Lst1-Sec23 with Atg40 at distinct ER domains to package ER into autophagosomes. Lst1-mediated ER-phagy played a vital role in maintaining cellular homeostasis by preventing the accumulation of an aggregationprone protein in the ER. Lst1 function appears to be conserved because its mammalian homolog, SEC24C, was also required for ER-phagy. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000474432700031 |
WOS关键词 | UNFOLDED PROTEIN RESPONSE ; SELECTIVE AUTOPHAGY ; CARGO ; YEAST ; LUNAPARK ; PATHWAYS ; TURNOVER ; TRIGGERS ; REQUIRES ; TEX264 |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201803 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USA; 2.Univ Oslo, Inst Basic Med Sci, Dept Mol Med, Sognsvannsveien 9, N-0372 Oslo, Norway; 3.Univ Pittsburgh, Dept Biol Sci, Pittsburgh, PA 15260 USA; 4.Univ Groningen, Dept Biomed Sci Cells & Syst, Med Ctr, Groningen, Netherlands |
推荐引用方式 GB/T 7714 | Cui, Yixian,Parashar, Smriti,Zahoor, Muhammad,et al. A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation[J]. SCIENCE,2019,365(6448):53-60. |
APA | Cui, Yixian.,Parashar, Smriti.,Zahoor, Muhammad.,Needham, Patrick G..,Mari, Muriel.,...&Ferro-Novick, Susan.(2019).A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation.SCIENCE,365(6448),53-60. |
MLA | Cui, Yixian,et al."A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation".SCIENCE 365.6448(2019):53-60. |
条目包含的文件 | 条目无相关文件。 |
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