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DOI | 10.1126/science.aaw4912 |
A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation | |
Timms, Richard T.1,2; Zhang, Zhiqian1,2; Rhee, David Y.3; Harper, J. Wade3; Koren, Itay1,2,4; Elledge, Stephen J.1,2 | |
2019-07-05 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6448页码:45-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Israel |
英文摘要 | The N-terminal residue influences protein stability through N-degron pathways. We used stability profiling of the human N-terminome to uncover multiple additional features of N-degron pathways. In addition to uncovering extended specificities of UBR E3 ligases, we characterized two related Cullin-RING E3 ligase complexes, Cul2(ZYG11B) and Cul2(ZER1), that act redundantly to target N-terminal glycine. N-terminal glycine degrons are depleted at native N-termini but strongly enriched at caspase cleavage sites, suggesting roles for the substrate adaptors ZYG11B and ZER1 in protein degradation during apoptosis. Furthermore, ZYG11B and ZER1 were found to participate in the quality control of N-myristoylated proteins, in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation. Thus, an additional N-degron pathway specific for glycine regulates the stability of metazoan proteomes. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000474432700027 |
WOS关键词 | END RULE PATHWAY ; TERMINAL ACETYLATION ; DEGRADATION SIGNALS ; CELLULAR-PROTEINS ; ZYG-11 ; CUL-2 ; VISUALIZATION ; RECOGNITION ; PROTEOLYSIS ; METHIONINE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201799 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Brigham & Womens Hosp, Howard Hughes Med Inst, Dept Med, Div Genet, Boston, MA 02115 USA; 2.Harvard Med Sch, Dept Genet, Boston, MA 02115 USA; 3.Harvard Med Sch, Dept Cell Biol, Boston, MA 02115 USA; 4.Bar Ilan Univ, Mina & Everard Goodman Fac Life Sci, IL-5290002 Ramat Gan, Israel |
推荐引用方式 GB/T 7714 | Timms, Richard T.,Zhang, Zhiqian,Rhee, David Y.,et al. A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation[J]. SCIENCE,2019,365(6448):45-+. |
APA | Timms, Richard T.,Zhang, Zhiqian,Rhee, David Y.,Harper, J. Wade,Koren, Itay,&Elledge, Stephen J..(2019).A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation.SCIENCE,365(6448),45-+. |
MLA | Timms, Richard T.,et al."A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation".SCIENCE 365.6448(2019):45-+. |
条目包含的文件 | 条目无相关文件。 |
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