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DOI | 10.1126/science.aat9557 |
A liquid-like spindle domain promotes acentrosomal spindle assembly in mammalian oocytes | |
So, Chun1; Seres, K. Bianka1,2,3; Steyer, Anna M.4,5; Moennich, Eike1; Clift, Dean2; Pejkovska, Anastasija1; Moebius, Wiebke4,5; Schuh, Melina1,2 | |
2019-06-28 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6447页码:1252-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; England |
英文摘要 | Mammalian oocytes segregate chromosomes with a microtubule spindle that lacks centrosomes, but the mechanisms by which acentrosomal spindles are organized and function are largely unclear. In this study, we identify a conserved subcellular structure in mammalian oocytes that forms by phase separation. This structure, which we term the liquid-like meiotic spindle domain (LISD), permeates the spindle poles and forms dynamic protrusions that extend well beyond the spindle. The LISD selectively concentrates multiple microtubule regulatory factors and allows them to diffuse rapidly within the spindle volume. Disruption of the LISD via different means disperses these factors and leads to severe spindle assembly defects. Our data suggest a model whereby the LISD promotes meiotic spindle assembly by serving as a reservoir that sequesters and mobilizes microtubule regulatory factors in proximity to spindle microtubules. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000473271300038 |
WOS关键词 | CHROMOSOME ALIGNMENT ; MOUSE OOCYTES ; MEIOTIC SPINDLE ; GAMMA-TUBULIN ; MICROTUBULE ORGANIZATION ; FLUORESCENT PROTEINS ; CENTROSOMAL PROTEINS ; CRITICAL REGULATOR ; ACENTRIOLAR MTOCS ; MITOTIC SPINDLES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201758 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Max Planck Inst Biophys Chem, Dept Meiosis, D-37077 Gottingen, Germany; 2.MRC, Mol Biol Lab, Cambridge CB2 0QH, England; 3.Bourn Hall Clin, Cambridge CB23 2TN, England; 4.Max Planck Inst Expt Med, Dept Neurogenet, Electron Microscopy Core Unit, D-37075 Gottingen, Germany; 5.Cluster Excellence Nanoscale Microscopy & Mol Phy, D-37073 Gottingen, Germany |
推荐引用方式 GB/T 7714 | So, Chun,Seres, K. Bianka,Steyer, Anna M.,et al. A liquid-like spindle domain promotes acentrosomal spindle assembly in mammalian oocytes[J]. SCIENCE,2019,364(6447):1252-+. |
APA | So, Chun.,Seres, K. Bianka.,Steyer, Anna M..,Moennich, Eike.,Clift, Dean.,...&Schuh, Melina.(2019).A liquid-like spindle domain promotes acentrosomal spindle assembly in mammalian oocytes.SCIENCE,364(6447),1252-+. |
MLA | So, Chun,et al."A liquid-like spindle domain promotes acentrosomal spindle assembly in mammalian oocytes".SCIENCE 364.6447(2019):1252-+. |
条目包含的文件 | 条目无相关文件。 |
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