Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aax1184 |
Obesity remodels activity and transcriptional state of a lateral hypothalamic brake on feeding | |
Rossi, Mark A.1,9; Basiri, Marcus L.1,9; McHenry, Jenna A.1; Kosyk, Oksana1; Otis, James M.1; van den Munkhof, Hanna E.1; Bryois, Julien2; Hubel, Christopher2,3,4; Breen, Gerome3,4; Guo, Wilson1; Bulik, Cynthia M.1,2,5; Sullivan, Patrick F.2,6; Stuber, Garret D.1,7,8,9 | |
2019-06-28 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6447页码:1271-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Sweden; England |
英文摘要 | The current obesity epidemic is a major worldwide health concern. Despite the consensus that the brain regulates energy homeostasis, the neural adaptations governing obesity are unknown. Using a combination of high-throughput single-cell RNA sequencing and longitudinal in vivo two-photon calcium imaging, we surveyed functional alterations of the lateral hypothalamic area (LHA)-a highly conserved brain region that orchestrates feeding-in a mouse model of obesity. The transcriptional profile of LHA glutamatergic neurons was affected by obesity, exhibiting changes indicative of altered neuronal activity. Encoding properties of individual LHA glutamatergic neurons were then tracked throughout obesity, revealing greatly attenuated reward responses. These data demonstrate how diet disrupts the function of an endogenous feeding suppression system to promote overeating and obesity. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000473271300045 |
WOS关键词 | CIRCUITS ; DYNAMICS ; NEURONS ; SYSTEMS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201746 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA; 2.Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden; 3.Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England; 4.South London & Maudsley Hosp, UK Natl Inst Hlth Res Biomed Res Ctr, London, England; 5.Univ N Carolina, Dept Nutr, Chapel Hill, NC 27599 USA; 6.Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA; 7.Univ N Carolina, Neurosci Ctr, Chapel Hill, NC 27599 USA; 8.Univ N Carolina, Dept Cell Biol & Physiol, Chapel Hill, NC 27599 USA; 9.Univ Washington, Dept Anesthesiol & Pain Med, Dept Pharmacol, Ctr Neurobiol Addict Pain & Emot, Seattle, WA 98199 USA |
推荐引用方式 GB/T 7714 | Rossi, Mark A.,Basiri, Marcus L.,McHenry, Jenna A.,et al. Obesity remodels activity and transcriptional state of a lateral hypothalamic brake on feeding[J]. SCIENCE,2019,364(6447):1271-+. |
APA | Rossi, Mark A..,Basiri, Marcus L..,McHenry, Jenna A..,Kosyk, Oksana.,Otis, James M..,...&Stuber, Garret D..(2019).Obesity remodels activity and transcriptional state of a lateral hypothalamic brake on feeding.SCIENCE,364(6447),1271-+. |
MLA | Rossi, Mark A.,et al."Obesity remodels activity and transcriptional state of a lateral hypothalamic brake on feeding".SCIENCE 364.6447(2019):1271-+. |
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