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DOI | 10.1126/science.aaw4852 |
Cryo-EM structure of the mammalian ATP synthase tetramer bound with inhibitory protein IF1 | |
Gu, Jinke1; Zhang, Laixing1; Zong, Shuai1; Guo, Runyu1; Liu, Tianya1; Yi, Jingbo1; Wang, Peiyi2; Zhuo, Wei1; Yang, Maojun1,3 | |
2019-06-14 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6445页码:1068-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
英文摘要 | The mitochondrial adenosine triphosphate (ATP) synthase produces most of the ATP required by mammalian cells. We isolated porcine tetrameric ATP synthase and solved its structure at 6.2-angstrom resolution using a single-particle cryo-electron microscopy method. Two classical V-shaped ATP synthase dimers lie antiparallel to each other to form an H-shaped ATP synthase tetramer, as viewed from the matrix. ATP synthase inhibitory factor subunit 1 (IF1) is a well-known in vivo inhibitor of mammalian ATP synthase at low pH. Two IF1 dimers link two ATP synthase dimers, which is consistent with the ATP synthase tetramer adopting an inhibited state. Within the tetramer, we refined structures of intact ATP synthase in two different rotational conformations at 3.34- and 3.45-angstrom resolution. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000471306700041 |
WOS关键词 | INNER MITOCHONDRIAL-MEMBRANE ; BEAM-INDUCED MOTION ; REGULATORY PROTEIN ; F-1-ATPASE ; RESOLUTION ; ARCHITECTURE ; SUBUNIT ; CRISTAE ; DOMAIN ; ORGANIZATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201654 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Tsinghua Univ, Sch Life Sci, Beijing Adv Innovat Ctr Struct Biol, Minist Educ,Key Lab Prot Sci,Tsinghua Peking Join, Beijing 100084, Peoples R China; 2.Southern Univ Sci & Technol, SUSTech CryoEM Facil Ctr, Shenzhen 518055, Peoples R China; 3.Huazhong Univ Sci & Technol, Sch Pharm, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China |
推荐引用方式 GB/T 7714 | Gu, Jinke,Zhang, Laixing,Zong, Shuai,et al. Cryo-EM structure of the mammalian ATP synthase tetramer bound with inhibitory protein IF1[J]. SCIENCE,2019,364(6445):1068-+. |
APA | Gu, Jinke.,Zhang, Laixing.,Zong, Shuai.,Guo, Runyu.,Liu, Tianya.,...&Yang, Maojun.(2019).Cryo-EM structure of the mammalian ATP synthase tetramer bound with inhibitory protein IF1.SCIENCE,364(6445),1068-+. |
MLA | Gu, Jinke,et al."Cryo-EM structure of the mammalian ATP synthase tetramer bound with inhibitory protein IF1".SCIENCE 364.6445(2019):1068-+. |
条目包含的文件 | 条目无相关文件。 |
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