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DOI | 10.1126/science.aav7617 |
Prenatal activity from thalamic neurons governs the emergence of functional cortical maps in mice | |
Anton-Bolanos, Noelia1; Sempere-Ferrandez, Alejandro1; Guillamon-Vivancos, Teresa1; Martini, Francisco J.1; Perez-Saiz, Leticia1; Gezelius, Henrik1; Filipchuk, Anton1,2; Valdeolmillos, Miguel1; Lopez-Bendito, Guillermina1 | |
2019-06-07 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6444页码:987-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Spain; France |
英文摘要 | The mammalian brain's somatosensory cortex is a topographic map of the body's sensory experience. In mice, cortical barrels reflect whisker input. We asked whether these cortical structures require sensory input to develop or are driven by intrinsic activity. Thalamocortical columns, connecting the thalamus to the cortex, emerge before sensory input and concur with calcium waves in the embryonic thalamus. We show that the columnar organization of the thalamocortical somatotopic map exists in the mouse embryo before sensory input, thus linking spontaneous embryonic thalamic activity to somatosensory map formation. Without thalamic calcium waves, cortical circuits become hyperexcitable, columnar and barrel organization does not emerge, and the somatosensory map lacks anatomical and functional structure. Thus, a self-organized protomap in the embryonic thalamus drives the functional assembly of murine thalamocortical sensory circuits. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000471079600007 |
WOS关键词 | CEREBRAL-CORTEX ; CRITICAL PERIOD ; NETWORK OSCILLATIONS ; NEWBORN RAT ; ORGANIZATION ; ACTIVATION ; BARRELS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201599 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.UMH CSIC, Inst Neurociencias Alicante, Sant Joan dAlacant, Spain; 2.Univ Paris Sud, Dept Integrat & Computat Neurosci ICN, Paris Saclay Inst Neurosci NeuroPSI, CNRS, F-91198 Gif Sur Yvette, France |
推荐引用方式 GB/T 7714 | Anton-Bolanos, Noelia,Sempere-Ferrandez, Alejandro,Guillamon-Vivancos, Teresa,et al. Prenatal activity from thalamic neurons governs the emergence of functional cortical maps in mice[J]. SCIENCE,2019,364(6444):987-+. |
APA | Anton-Bolanos, Noelia.,Sempere-Ferrandez, Alejandro.,Guillamon-Vivancos, Teresa.,Martini, Francisco J..,Perez-Saiz, Leticia.,...&Lopez-Bendito, Guillermina.(2019).Prenatal activity from thalamic neurons governs the emergence of functional cortical maps in mice.SCIENCE,364(6444),987-+. |
MLA | Anton-Bolanos, Noelia,et al."Prenatal activity from thalamic neurons governs the emergence of functional cortical maps in mice".SCIENCE 364.6444(2019):987-+. |
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