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DOI | 10.1126/science.aaw5842 |
Social transmission of food safety depends on synaptic plasticity in the prefrontal cortex | |
Loureiro, Michael1; Achargui, Ridouane1; Flakowski, Jerome1; Van Zessen, Ruud1; Stefanelli, Thomas1; Pascoli, Vincent1; Luescher, Christian1,2 | |
2019-06-07 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6444页码:991-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Switzerland |
英文摘要 | When an animal is facing unfamiliar food, its odor, together with semiochemicals emanating from a conspecific, can constitute a safety message and authorize intake. The piriform cortex (PiC) codes olfactory information, and the inactivation of neurons in the nucleus accumbens (NAc) can acutely trigger consumption. However, the neural circuit and cellular substrate of transition of olfactory perception into value-based actions remain elusive. We detected enhanced activity after social transmission between two mice in neurons of the medial prefrontal cortex (mPFC) that target the NAc and receive projections from the PiC. Exposure to a conspecific potentiated the excitatory postsynaptic currents in NAc projectors, whereas blocking transmission from PiC to mPFC prevented social transmission. Thus, synaptic plasticity in the mPFC is a cellular substrate of social transmission of food safety. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000471079600008 |
WOS关键词 | OLFACTORY MEMORY ; ENERGY-BALANCE ; NEURONS ; INPUT |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201593 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Geneva, Med Fac, Dept Basic Neurosci, CH-1211 Geneva, Switzerland; 2.Geneva Univ Hosp, Dept Clin Neurosci, Clin Neurol, CH-1211 Geneva, Switzerland |
推荐引用方式 GB/T 7714 | Loureiro, Michael,Achargui, Ridouane,Flakowski, Jerome,et al. Social transmission of food safety depends on synaptic plasticity in the prefrontal cortex[J]. SCIENCE,2019,364(6444):991-+. |
APA | Loureiro, Michael.,Achargui, Ridouane.,Flakowski, Jerome.,Van Zessen, Ruud.,Stefanelli, Thomas.,...&Luescher, Christian.(2019).Social transmission of food safety depends on synaptic plasticity in the prefrontal cortex.SCIENCE,364(6444),991-+. |
MLA | Loureiro, Michael,et al."Social transmission of food safety depends on synaptic plasticity in the prefrontal cortex".SCIENCE 364.6444(2019):991-+. |
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