Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aaw0474 |
Insular cortex processes aversive somatosensory information and is crucial for threat learning | |
Berret, Emmanuelle; Kintscher, Michael; Palchaudhuri, Shriya; Tang, Wei; Osypenko, Denys; Kochubey, Olexiy; Schneggenburger, Ralf | |
2019-05-31 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6443页码:850-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Switzerland |
英文摘要 | Learning about threats is essential for survival. During threat learning, an innocuous sensory percept such as a tone acquires an emotional meaning when paired with an aversive stimulus such as a mild footshock. The amygdala is critical for threat memory formation, but little is known about upstream brain areas that process aversive somatosensory information. Using optogenetic techniques in mice, we found that silencing of the posterior insula during footshock reduced acute fear behavior and impaired 1- day threat memory. Insular cortex neurons respond to footshocks, acquire responses to tones during threat learning, and project to distinct amygdala divisions to drive acute fear versus threat memory formation. Thus, the posterior insula conveys aversive footshock information to the amygdala and is crucial for learning about potential dangers in the environment. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000469887900053 |
WOS关键词 | NEURAL ENSEMBLE ; FEAR ; AMYGDALA ; PATHWAYS ; CIRCUIT ; MEMORY ; RESPONSES ; BEHAVIOR ; TASTE ; PAIN |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201523 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | Ecole Polytech Fed Lausanne, Sch Life Sci, Brain & Mind Inst, Lab Synapt Mech, CH-1015 Lausanne, Switzerland |
推荐引用方式 GB/T 7714 | Berret, Emmanuelle,Kintscher, Michael,Palchaudhuri, Shriya,et al. Insular cortex processes aversive somatosensory information and is crucial for threat learning[J]. SCIENCE,2019,364(6443):850-+. |
APA | Berret, Emmanuelle.,Kintscher, Michael.,Palchaudhuri, Shriya.,Tang, Wei.,Osypenko, Denys.,...&Schneggenburger, Ralf.(2019).Insular cortex processes aversive somatosensory information and is crucial for threat learning.SCIENCE,364(6443),850-+. |
MLA | Berret, Emmanuelle,et al."Insular cortex processes aversive somatosensory information and is crucial for threat learning".SCIENCE 364.6443(2019):850-+. |
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