Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aaw0445 |
Brainstem nucleus incertus controls contextual memory formation | |
Szonyi, Andras1,2; Sos, Katalin E.1,2; Nyilas, Rita3; Schlingloff, Daniel1,2; Domonkos, Andor1; Takacs, Virag T.1; Posfai, Balazs1,2; Hegedus, Panna1,2; Priestley, James B.3; Gundlach, Andrew L.4; Gulyas, Attila I.1; Varga, Viktor1; Losonczy, Attila3; Freund, Tamas F.1; Nyiri, Gabor1 | |
2019-05-24 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6442页码:752-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Hungary; USA; Australia |
英文摘要 | Hippocampal pyramidal cells encode memory engrams, which guide adaptive behavior. Selection of engram-forming cells is regulated by somatostatin-positive dendrite-targeting interneurons, which inhibit pyramidal cells that are not required for memory formation. Here, we found that gamma-aminobutyric acid ( GABA)-releasing neurons of the mouse nucleus incertus (NI) selectively inhibit somatostatin-positive interneurons in the hippocampus, both monosynaptically and indirectly through the inhibition of their subcortical excitatory inputs. We demonstrated that NI GABAergic neurons receive monosynaptic inputs from brain areas processing important environmental information, and their hippocampal projections are strongly activated by salient environmental inputs in vivo. Optogenetic manipulations of NI GABAergic neurons can shift hippocampal network state and bidirectionally modify the strength of contextual fear memory formation. Our results indicate that brainstem NI GABAergic cells are essential for controlling contextual memories. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E ; SSCI |
WOS记录号 | WOS:000469296000036 |
WOS关键词 | CORTICOTROPIN-RELEASING-FACTOR ; SEPTAL CHOLINERGIC NEURONS ; HIPPOCAMPAL-THETA-RHYTHM ; GABAERGIC NEURONS ; DORSAL HIPPOCAMPUS ; ENTORHINAL CORTEX ; CA1 REGION ; MEDIAL SEPTUM ; INTERNEURONS ; CELLS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201481 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Hungarian Acad Sci, Inst Expt Med, Dept Cellular & Network Neurobiol, Lab Cerebral Cortex Res, Budapest, Hungary; 2.Semmelweis Univ, Janos Szentagothai Doctoral Sch Neurosci, Budapest, Hungary; 3.Columbia Univ, Kavli Inst Brain Sci, Mortimer B Zuckerman Mind Brain Behav Inst, Dept Neurosci, New York, NY USA; 4.Florey Inst Neurosci & Mental Hlth, Peptide Neurobiol Lab, Parkville, Vic, Australia |
推荐引用方式 GB/T 7714 | Szonyi, Andras,Sos, Katalin E.,Nyilas, Rita,et al. Brainstem nucleus incertus controls contextual memory formation[J]. SCIENCE,2019,364(6442):752-+. |
APA | Szonyi, Andras.,Sos, Katalin E..,Nyilas, Rita.,Schlingloff, Daniel.,Domonkos, Andor.,...&Nyiri, Gabor.(2019).Brainstem nucleus incertus controls contextual memory formation.SCIENCE,364(6442),752-+. |
MLA | Szonyi, Andras,et al."Brainstem nucleus incertus controls contextual memory formation".SCIENCE 364.6442(2019):752-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论