Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aav8130 |
Single-cell genomics identifies cell type-specific molecular changes in autism | |
Velmeshev, Dmitry1,2; Schirmer, Lucas1,3,4; Jung, Diane1,2; Haeussler, Maximilian5; Perez, Yonatan1,2; Mayer, Simone1,2,6; Bhaduri, Aparna1,2; Goyal, Nitasha1,2,7; Rowitch, David H.1,3,8,9,10; Kriegstein, Arnold R.1,2 | |
2019-05-17 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6441页码:685-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Germany; England |
英文摘要 | Despite the clinical and genetic heterogeneity of autism, bulk gene expression studies show that changes in the neocortex of autism patients converge on common genes and pathways. However, direct assessment of specific cell types in the brain affected by autism has not been feasible until recently. We used single-nucleus RNA sequencing of cortical tissue from patients with autism to identify autism-associated transcriptomic changes in specific cell types. We found that synaptic signaling of upper-layer excitatory neurons and the molecular state of microglia are preferentially affected in autism. Moreover, our results show that dysregulation of specific groups of genes in cortico-cortical projection neurons correlates with clinical severity of autism. These findings suggest that molecular changes in upper-layer cortical circuits are linked to behavioral manifestations of autism. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000468551000035 |
WOS关键词 | GENE-EXPRESSION ; CLASSIFICATION ; FRAMEWORK ; NEURONS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201447 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Calif San Francisco, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, San Francisco, CA 94143 USA; 2.Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA; 3.Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA; 4.Heidelberg Univ, Med Fac Mannheim, Dept Neurol, D-68167 Mannheim, Germany; 5.Univ Calif Santa Cruz, Genom Inst, Santa Cruz, CA 95064 USA; 6.Univ Tubingen, Hertie Inst Clin Brain Res, D-72076 Tubingen, Germany; 7.Univ Calif Berkeley, Dept Mol & Cell Biol, 229 Stanley Hall, Berkeley, CA 94720 USA; 8.Univ Cambridge, Dept Paediat, Cambridge CB2 0QQ, England; 9.Univ Cambridge, Wellcome Trust MRC Cambridge Stem Cell Inst, Cambridge CB2 0QQ, England; 10.Univ Calif San Francisco, Dept Neurosurg, San Francisco, CA 94143 USA |
推荐引用方式 GB/T 7714 | Velmeshev, Dmitry,Schirmer, Lucas,Jung, Diane,et al. Single-cell genomics identifies cell type-specific molecular changes in autism[J]. SCIENCE,2019,364(6441):685-+. |
APA | Velmeshev, Dmitry.,Schirmer, Lucas.,Jung, Diane.,Haeussler, Maximilian.,Perez, Yonatan.,...&Kriegstein, Arnold R..(2019).Single-cell genomics identifies cell type-specific molecular changes in autism.SCIENCE,364(6441),685-+. |
MLA | Velmeshev, Dmitry,et al."Single-cell genomics identifies cell type-specific molecular changes in autism".SCIENCE 364.6441(2019):685-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论