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DOI | 10.1126/science.aav9996 |
Identification of a regeneration-organizing cell in the Xenopus tail | |
Aztekin, C.1,2; Hiscock, T. W.1,3; Marioni, J. C.3,4,5; Gurdon, J. B.1,2; Simons, B. D.1,6,7; Jullien, J.1,2 | |
2019-05-17 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6441页码:653-+ |
文章类型 | Article |
语种 | 英语 |
国家 | England |
英文摘要 | Unlike mammals, Xenopus laevis tadpoles have a high regenerative potential. To characterize this regenerative response, we performed single-cell RNA sequencing after tail amputation. By comparing naturally occurring regeneration-competent and -incompetent tadpoles, we identified a previously unrecognized cell type, which we term the regeneration-organizing cell (ROC). ROCs are present in the epidermis during normal tail development and specifically relocalize to the amputation plane of regeneration-competent tadpoles, forming the wound epidermis. Genetic ablation or manual removal of ROCs blocks regeneration, whereas transplantation of ROC-containing grafts induces ectopic outgrowths in early embryos. Transcriptional profiling revealed that ROCs secrete ligands associated with key regenerative pathways, signaling to progenitors to reconstitute lost tissue. These findings reveal the cellular mechanism through which ROCs form the wound epidermis and ensure successful regeneration. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000468551000027 |
WOS关键词 | TISSUE-REPAIR ; SPINAL-CORD ; EXPRESSION ; LIMB ; TRANSGENESIS ; REQUIREMENT ; NETWORK ; TOOL |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201444 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Cambridge, Wellcome Trust Canc Res UK, Gurdon Inst, Cambridge, England; 2.Univ Cambridge, Dept Zool, Cambridge, England; 3.Univ Cambridge, Canc Res UK Cambridge Inst, Cambridge, England; 4.EMBL European Bioinformat Inst, Wellcome Genome Campus, Cambridge, England; 5.Wellcome Sanger Inst, Wellcome Genome Campus, Cambridge, England; 6.Univ Cambridge, Ctr Math Sci, Dept Appl Math & Theoret Phys, Cambridge, England; 7.Univ Cambridge, Wellcome Trust Ctr Stem Cell Res, Cambridge, England |
推荐引用方式 GB/T 7714 | Aztekin, C.,Hiscock, T. W.,Marioni, J. C.,et al. Identification of a regeneration-organizing cell in the Xenopus tail[J]. SCIENCE,2019,364(6441):653-+. |
APA | Aztekin, C.,Hiscock, T. W.,Marioni, J. C.,Gurdon, J. B.,Simons, B. D.,&Jullien, J..(2019).Identification of a regeneration-organizing cell in the Xenopus tail.SCIENCE,364(6441),653-+. |
MLA | Aztekin, C.,et al."Identification of a regeneration-organizing cell in the Xenopus tail".SCIENCE 364.6441(2019):653-+. |
条目包含的文件 | 条目无相关文件。 |
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