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DOI | 10.1126/science.aat8789 |
Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus | |
Luna, Victor M.1,2; Anacker, Christoph1,2,3; Burghardt, Nesha S.4,5; Khandaker, Hameda4,5; Andreu, Valentine1,2; Millette, Amaira1,2; Leary, Paige6,7,8,9; Ravenelle, Rebecca4,10; Jimenez, Jessica C.1,2; Mastrodonato, Alessia1,2; Denny, Christine A.1,2; Fenton, Andre A.11,12; Scharfman, Helen E.6,7,8,9; Hen, Rene1,2 | |
2019-05-10 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6440页码:578-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Young adult-born granule cells (abGCs) in the dentate gyrus (DG) have a profound impact on cognition and mood. However, it remains unclear how abGCs distinctively contribute to local DG information processing. We found that the actions of abGCs in the DG depend on the origin of incoming afferents. In response to lateral entorhinal cortex (LEC) inputs, abGCs exert monosynaptic inhibition of mature granule cells (mGCs) through group II metabotropic glutamate receptors. By contrast, in response to medial entorhinal cortex (MEC) inputs, abGCs directly excite mGCs through N-methyl-D-aspartate receptors. Thus, a critical function of abGCs may be to regulate the relative synaptic strengths of LEO-driven contextual information versus MEC-driven spatial information to shape distinct neural representations in the DG. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000467631800041 |
WOS关键词 | COGNITIVE FLEXIBILITY ; PERFORANT PATH ; NEUROGENESIS ; MEMORY ; CELLS ; EXPERIENCE ; 4-AMINOPYRIDINE ; ORGANIZATION ; ACTIVATION ; CURRENTS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201403 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Columbia Univ, Dept Psychiat, Div Syst Neurosci, New York, NY 10032 USA; 2.New York State Psychiat Inst & Hosp, Res Fdn Mental Hyg, New York, NY 10032 USA; 3.Sackler Inst Dev Psychobiol, New York, NY 10065 USA; 4.CUNY Hunter Coll, Dept Psychol, New York, NY 10021 USA; 5.CUNY, Grad Ctr, Dept Psychol, New York, NY 10016 USA; 6.New York Univ Langone Hlth, Dept Child & Adolescent Psychiat, New York, NY 10016 USA; 7.New York Univ Langone Hlth, Dept Neurosci & Physiol, New York, NY 10016 USA; 8.New York Univ Langone Hlth, Dept Psychiat, New York, NY 10016 USA; 9.New York Univ Langone Hlth, Neurosci Inst, New York, NY 10016 USA; 10.CUNY, Grad Ctr, Dept Biol, New York, NY 10021 USA; 11.NYU, Ctr Neural Sci, New York, NY 10003 USA; 12.Suny Downstate Med Ctr, Brooklyn, NY 11203 USA |
推荐引用方式 GB/T 7714 | Luna, Victor M.,Anacker, Christoph,Burghardt, Nesha S.,et al. Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus[J]. SCIENCE,2019,364(6440):578-+. |
APA | Luna, Victor M..,Anacker, Christoph.,Burghardt, Nesha S..,Khandaker, Hameda.,Andreu, Valentine.,...&Hen, Rene.(2019).Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus.SCIENCE,364(6440),578-+. |
MLA | Luna, Victor M.,et al."Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus".SCIENCE 364.6440(2019):578-+. |
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