Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aat8266 |
yyy HUMAN GENOMICS Chromatin three-dimensional interactions mediate genetic effects on gene expression | |
Delaneau, O.1,2,3,8; Zazhytska, M.4; Borel, C.1,3; Giannuzzi, G.4; Rey, G.1,2,3; Howald, C.1,2,3; Kumar, S.5,6; Ongen, H.1,2,3; Popadin, K.4,6,7; Marbach, D.6,8; Ambrosini, G.5,6; Bielser, D.1; Hacker, D.9; Romano, L.1; Ribaux, P.1; Wiederkehr, M.4; Falconnet, E.1; Bucher, P.5,6; Bergmann, S.6,8,10; Antonarakis, S. E.1,3; Reymond, A.4; Dermitzakis, E. T.1,2,3 | |
2019-05-03 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6439页码:452-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Switzerland; Russia; South Africa |
英文摘要 | Studying the genetic basis of gene expression and chromatin organization is key to characterizing the effect of genetic variability on the function and structure of the human genome. Here we unravel how genetic variation perturbs gene regulation using a dataset combining activity of regulatory elements, gene expression, and genetic variants across 317 individuals and two cell types. We show that variability in regulatory activity is structured at the intra-and interchromosomal levels within 12,583 cis-regulatory domains and 30 trans-regulatory hubs that highly reflect the local (that is, topologically associating domains) and global (that is, open and closed chromatin compartments) nuclear chromatin organization. These structures delimit cell type-specific regulatory networks that control gene expression and coexpression and mediate the genetic effects of cis- and trans-acting regulatory variants on genes. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000466809600024 |
WOS关键词 | TRANSCRIPTION FACTORS ; WIDE ASSOCIATION ; DNA-BINDING ; PHASE-SEPARATION ; DISEASE ; ARCHITECTURE ; PRINCIPLES ; DISCOVERY ; ALIGNMENT ; ACCURATE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201355 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Geneva, Dept Genet Med & Dev, Geneva, Switzerland; 2.Univ Geneva, Swiss Inst Bioinformat, Geneva, Switzerland; 3.Univ Geneva, Inst Genet & Genom Geneva, Geneva, Switzerland; 4.Univ Lausanne, Fac Biol & Med, Ctr Integrat Genom, Lausanne, Switzerland; 5.Ecole Polytech Fed Lausanne, Swiss Inst Expt Canc Res, Lausanne, Switzerland; 6.Swiss Inst Bioinformat, Lausanne, Switzerland; 7.Immanuel Kant Fed Balt Univ, Sch Life Sci, Kaliningrad, Russia; 8.Univ Lausanne, Dept Computat Biol, Lausanne, Switzerland; 9.Ecole Polytech Fed Lausanne, Sch Life Sci, Prot Express Core Facil, Lausanne, Switzerland; 10.Werner Beit North Fac Hlth Sci, Computat Biol Div N1 05, Cape Town, South Africa |
推荐引用方式 GB/T 7714 | Delaneau, O.,Zazhytska, M.,Borel, C.,et al. yyy HUMAN GENOMICS Chromatin three-dimensional interactions mediate genetic effects on gene expression[J]. SCIENCE,2019,364(6439):452-+. |
APA | Delaneau, O..,Zazhytska, M..,Borel, C..,Giannuzzi, G..,Rey, G..,...&Dermitzakis, E. T..(2019).yyy HUMAN GENOMICS Chromatin three-dimensional interactions mediate genetic effects on gene expression.SCIENCE,364(6439),452-+. |
MLA | Delaneau, O.,et al."yyy HUMAN GENOMICS Chromatin three-dimensional interactions mediate genetic effects on gene expression".SCIENCE 364.6439(2019):452-+. |
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