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DOI | 10.1126/science.aav9750 |
BIOMEDICINE Multivascular networks and functional intravascular topologies within biocompatible hydrogels | |
Grigoryan, Bagrat1; Paulsen, Samantha J.1; Corbett, Daniel C.2,3; Sazer, Daniel W.1; Fortin, Chelsea L.3,4; Zaita, Alexander J.1; Greenfield, Paul T.1; Calafat, Nicholas J.1; Gounley, John P.8; Ta, Anderson H.1; Johansson, Fredrik2,3; Randles, Amanda5; Rosenkrantz, Jessica E.6; Louis-Rosenberg, Jesse D.6; Galie, Peter A.7; Stevens, Kelly R.2,3,4; Miller, Jordan S.1 | |
2019-05-03 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6439页码:458-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Solid organs transport fluids through distinct vascular networks that are biophysically and biochemically entangled, creating complex three-dimensional (3D) transport regimes that have remained difficult to produce and study. We establish intravascular andmultivascular design freedoms with photopolymerizable hydrogels by using food dye additives as biocompatible yet potent photoabsorbers for projection stereolithography. We demonstrate monolithic transparent hydrogels, produced in minutes, comprising efficient intravascular 3D fluid mixers and functional bicuspid valves. We further elaborate entangled vascular networks from space-filling mathematical topologies and explore the oxygenation and flow of human red blood cells during tidal ventilation and distension of a proximate airway. In addition, we deploy structured biodegradable hydrogel carriers in a rodent model of chronic liver injury to highlight the potential translational utility of this materials innovation. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000466809600028 |
WOS关键词 | LUNG STRUCTURE ; HEART-VALVES ; BLOOD-FLOW ; MODEL ; STEREOLITHOGRAPHY ; NANOPARTICLES ; PERFORMANCE ; FABRICATION ; EVOLUTION ; SYSTEM |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201347 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Rice Univ, Dept Bioengn, Houston, TX 77005 USA; 2.Univ Washington, Dept Bioengn, Seattle, WA 98195 USA; 3.Univ Washington, Inst Stem Cell & Regenerat Med, Seattle, WA 98195 USA; 4.Univ Washington, Dept Pathol, Seattle, WA 98195 USA; 5.Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA; 6.Nervous Syst, Somerville, MA 02143 USA; 7.Rowan Univ, Dept Biomed Engn, Glassboro, NJ 08028 USA; 8.Oak Ridge Natl Lab, Computat Sci & Engn Div, Oak Ridge, TN 37830 USA |
推荐引用方式 GB/T 7714 | Grigoryan, Bagrat,Paulsen, Samantha J.,Corbett, Daniel C.,et al. BIOMEDICINE Multivascular networks and functional intravascular topologies within biocompatible hydrogels[J]. SCIENCE,2019,364(6439):458-+. |
APA | Grigoryan, Bagrat.,Paulsen, Samantha J..,Corbett, Daniel C..,Sazer, Daniel W..,Fortin, Chelsea L..,...&Miller, Jordan S..(2019).BIOMEDICINE Multivascular networks and functional intravascular topologies within biocompatible hydrogels.SCIENCE,364(6439),458-+. |
MLA | Grigoryan, Bagrat,et al."BIOMEDICINE Multivascular networks and functional intravascular topologies within biocompatible hydrogels".SCIENCE 364.6439(2019):458-+. |
条目包含的文件 | 条目无相关文件。 |
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