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DOI | 10.1126/science.aav2501 |
Identification of a mesenchymal progenitor cell hierarchy in adipose tissue | |
Merrick, David1,2; Sakers, Alexander1,2; Irgebay, Zhazira1,2; Okada, Chihiro1,2; Calvert, Catherine3; Morley, Michael P.4; Percec, Ivona3; Seale, Patrick1,2 | |
2019-04-26 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6438页码:353-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Metabolic health depends on the capacity of adipose tissue progenitor cells to undergo de novo adipogenesis. The cellular hierarchy and mechanisms governing adipocyte progenitor differentiation are incompletely understood. Through single-cell RNA sequence analyses, we show that the lineage hierarchy of adipocyte progenitors consists of distinct mesenchymal cell types that are present in both mouse and human adipose tissues. Cells marked by dipeptidyl peptidase-4 (DPP4)/CD26 expression are highly proliferative, multipotent progenitors. During the development of subcutaneous adipose tissue in mice, these progenitor cells give rise to intercellular adhesion molecule-1 (ICAM1)/CD54-expressing (CD54+) committed preadipocytes and a related adipogenic cell population marked by Clec11a and F3/CD142 expression. Transforming growth factor-b maintains DPP4+ cell identity and inhibits adipogenic commitment of DPP4+ and CD142+ cells. Notably, DPP4+ progenitors reside in the reticular interstitium, a recently appreciated fluid-filled space within and between tissues, including adipose depots. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000465643400038 |
WOS关键词 | ADIPOCYTE ; PREADIPOCYTES ; ADIPOGENESIS ; ACCUMULATION ; CONTRIBUTE ; PRECURSORS ; OBESITY ; PREF-1 ; WNT |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201298 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Penn, Perelman Sch Med, Inst Diabet Obes & Metab, Philadelphia, PA 19104 USA; 2.Univ Penn, Perelman Sch Med, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA; 3.Univ Penn, Perelman Sch Med, Div Plast Surg, Philadelphia, PA 19104 USA; 4.Univ Penn, Perelman Sch Med, Penn Ctr Pulm Biol, Philadelphia, PA 19104 USA |
推荐引用方式 GB/T 7714 | Merrick, David,Sakers, Alexander,Irgebay, Zhazira,et al. Identification of a mesenchymal progenitor cell hierarchy in adipose tissue[J]. SCIENCE,2019,364(6438):353-+. |
APA | Merrick, David.,Sakers, Alexander.,Irgebay, Zhazira.,Okada, Chihiro.,Calvert, Catherine.,...&Seale, Patrick.(2019).Identification of a mesenchymal progenitor cell hierarchy in adipose tissue.SCIENCE,364(6438),353-+. |
MLA | Merrick, David,et al."Identification of a mesenchymal progenitor cell hierarchy in adipose tissue".SCIENCE 364.6438(2019):353-+. |
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