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DOI | 10.1126/science.aav3932 |
Thirst regulates motivated behavior through modulation of brainwide neural population dynamics | |
Allen, William E.1,2,3; Chen, Michael Z.1,2; Pichamoorthy, Nandini1; Tien, Rebecca H.1; Pachitariu, Marius4; Luo, Liqun2,5; Deisseroth, Karl1,5,6 | |
2019-04-19 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6437页码:253-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Physiological needs produce motivational drives, such as thirst and hunger, that regulate behaviors essential to survival. Hypothalamic neurons sense these needs and must coordinate relevant brainwide neuronal activity to produce the appropriate behavior. We studied dynamics from similar to 24,000 neurons in 34 brain regions during thirst-motivated choice behavior in 21 mice as they consumed water and became sated. Water-predicting sensory cues elicited activity that rapidly spread throughout the brain of thirsty animals. These dynamics were gated by a brainwide mode of population activity that encoded motivational state. After satiation, focal optogenetic activation of hypothalamic thirst-sensing neurons returned global activity to the pre-satiation state. Thus, motivational states specify initial conditions that determine how a brainwide dynamical system transforms sensory input into behavioral output. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000464956600040 |
WOS关键词 | FOOD CUE RESPONSES ; LATERAL HYPOTHALAMUS ; TRANSIENT DYNAMICS ; NEURONAL DYNAMICS ; ACTIVITY PATTERNS ; CORTEX ; CIRCUITS ; HUNGER ; REPRESENTATIONS ; MONKEY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201248 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA; 2.Stanford Univ, Dept Biol, Stanford, CA 94305 USA; 3.Stanford Univ, Neurosci Grad Program, Stanford, CA 94305 USA; 4.Janelia Res Campus, Ashburn, VA 20147 USA; 5.Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA; 6.Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA |
推荐引用方式 GB/T 7714 | Allen, William E.,Chen, Michael Z.,Pichamoorthy, Nandini,et al. Thirst regulates motivated behavior through modulation of brainwide neural population dynamics[J]. SCIENCE,2019,364(6437):253-+. |
APA | Allen, William E..,Chen, Michael Z..,Pichamoorthy, Nandini.,Tien, Rebecca H..,Pachitariu, Marius.,...&Deisseroth, Karl.(2019).Thirst regulates motivated behavior through modulation of brainwide neural population dynamics.SCIENCE,364(6437),253-+. |
MLA | Allen, William E.,et al."Thirst regulates motivated behavior through modulation of brainwide neural population dynamics".SCIENCE 364.6437(2019):253-+. |
条目包含的文件 | 条目无相关文件。 |
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