Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aav7893 |
Spontaneous behaviors drive multidimensional, brainwide activity | |
Stringer, Carsen1,2; Pachitariu, Marius1,3; Steinmetz, Nicholas4,5; Reddy, Charu Bai4; Carandini, Matteo4; Harris, Kenneth D.3 | |
2019-04-19 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6437页码:255-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; England |
英文摘要 | Neuronal populations in sensory cortex produce variable responses to sensory stimuli and exhibit intricate spontaneous activity even without external sensory input. Cortical variability and spontaneous activity have been variously proposed to represent random noise, recall of prior experience, or encoding of ongoing behavioral and cognitive variables. Recording more than 10,000 neurons in mouse visual cortex, we observed that spontaneous activity reliably encoded a high-dimensional latent state, which was partially related to the mouse's ongoing behavior and was represented not just in visual cortex but also across the forebrain. Sensory inputs did not interrupt this ongoing signal but added onto it a representation of external stimuli in orthogonal dimensions. Thus, visual cortical population activity, despite its apparently noisy structure, reliably encodes an orthogonal fusion of sensory and multidimensional behavioral information. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000464956600042 |
WOS关键词 | LOCOMOTION ; MODULATION ; STATE ; ORGANIZATION ; INFORMATION ; VARIABILITY ; PROJECTIONS ; MECHANISMS ; RESPONSES ; DYNAMICS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201244 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.HHMI Janelia Res Campus, Ashburn, VA 20147 USA; 2.UCL, Gatsby Computat Neurosci Unit, London W1T 4JG, England; 3.UCL Inst Neurol, London WC1E 6DE, England; 4.UCL Inst Ophthalmol, London EC1V 9EL, England; 5.Univ Washington, Dept Biol Struct, Seattle, WA 98195 USA |
推荐引用方式 GB/T 7714 | Stringer, Carsen,Pachitariu, Marius,Steinmetz, Nicholas,et al. Spontaneous behaviors drive multidimensional, brainwide activity[J]. SCIENCE,2019,364(6437):255-+. |
APA | Stringer, Carsen,Pachitariu, Marius,Steinmetz, Nicholas,Reddy, Charu Bai,Carandini, Matteo,&Harris, Kenneth D..(2019).Spontaneous behaviors drive multidimensional, brainwide activity.SCIENCE,364(6437),255-+. |
MLA | Stringer, Carsen,et al."Spontaneous behaviors drive multidimensional, brainwide activity".SCIENCE 364.6437(2019):255-+. |
条目包含的文件 | 条目无相关文件。 |
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