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DOI | 10.1126/science.aat0778 |
Deubiquitinase USP10 regulates Notch signaling in the endothelium | |
Lim, R.1; Sugino, T.1; Nolte, H.2,3; Andrade, J.1; Zimmermann, B.1; Shi, C.1; Doddaballapur, A.1; Ong, Y. T.1; Wilhelm, K.1; Fasse, J. W. D.1; Ernst, A.4,5; Kaulich, M.4; Husnjak, K.4; Boettger, T.6; Guenther, S.6; Braun, T.6; Krueger, M.2,3; Benedito, R.7; Dikic, I.4,8; Potente, M.1,9,10 | |
2019-04-12 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6436页码:188-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; Spain; Poland |
英文摘要 | Notch signaling is a core patterning module for vascular morphogenesis that codetermines the sprouting behavior of endothelial cells (ECs). Tight quantitative and temporal control of Notch activity is essential for vascular development, yet the details of Notch regulation in ECs are incompletely understood. We found that ubiquitin-specific peptidase 10 (USP10) interacted with the NOTCH1 intracellular domain (NICD1) to slow the ubiquitin-dependent turnover of this short-lived form of the activated NOTCH1 receptor. Accordingly, inactivation of USP10 reduced NICD1 abundance and stability and diminished Notch-induced target gene expression in ECs. In mice, the loss of endothelial Usp10 increased vessel sprouting and partially restored the patterning defects caused by ectopic expression of NICD1. Thus, USP10 functions as an NICD1 deubiquitinase that fine-tunes endothelial Notch responses during angiogenic sprouting. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000464620000045 |
WOS关键词 | CELL BEHAVIOR ; ACTIVATION ; ANGIOGENESIS ; PROTEINS ; DLL4 ; EFFICIENT ; VEGF |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201203 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Max Planck Inst Heart & Lung Res, Angiogenesis & Metab Lab, D-61231 Bad Nauheim, Germany; 2.Univ Cologne, Inst Genet, D-50931 Cologne, Germany; 3.Univ Cologne, Excellence Cluster Cellular Stress Responses Agin, D-50931 Cologne, Germany; 4.Goethe Univ, Inst Biochem 2, Fac Med, D-60590 Frankfurt, Germany; 5.Fraunhofer Inst Mol Biol & Appl Ecol IME, Project Grp Translat Med & Pharmacol TMP, D-60590 Frankfurt, Germany; 6.Max Planck Inst Heart & Lung Res, Dept Cardiac Dev & Remodeling, D-61231 Bad Nauheim, Germany; 7.CNIC, Mol Genet Angiogenesis Lab, Madrid 28029, Spain; 8.Goethe Univ, Buchmann Inst Mol Life Sci, D-60438 Frankfurt, Germany; 9.Partner Site Frankfurt Rhine Main, DZHK German Ctr Cardiovasc Res, D-13347 Berlin, Germany; 10.Int Inst Mol & Cell Biol, PL-02109 Warsaw, Poland |
推荐引用方式 GB/T 7714 | Lim, R.,Sugino, T.,Nolte, H.,et al. Deubiquitinase USP10 regulates Notch signaling in the endothelium[J]. SCIENCE,2019,364(6436):188-+. |
APA | Lim, R..,Sugino, T..,Nolte, H..,Andrade, J..,Zimmermann, B..,...&Potente, M..(2019).Deubiquitinase USP10 regulates Notch signaling in the endothelium.SCIENCE,364(6436),188-+. |
MLA | Lim, R.,et al."Deubiquitinase USP10 regulates Notch signaling in the endothelium".SCIENCE 364.6436(2019):188-+. |
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