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DOI | 10.1126/science.aat8515 |
High-fructose corn syrup enhances intestinal tumor growth in mice | |
Goncalves, Marcus D.1,2; Lu, Changyuan3; Tutnauer, Jordan1; Hartman, Travis E.4; Hwang, Seo-Kyoung1; Murphy, Charles J.1,5; Pauli, Chantal6; Morris, Roxanne4; Taylor, Sam1; Bosch, Kaitlyn7; Yang, Sukjin8; Wang, Yumei8; Van Riper, Justin8; Lekaye, H. Carl9; Roper, Jatin10; Kim, Young11; Chen, Qiuying3; Gross, Steven S.3; Rhee, Kyu Y.4; Cantley, Lewis C.1; Yun, Jihye8 | |
2019-03-22 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 363期号:6433页码:1345-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Switzerland; South Korea |
英文摘要 | Excessive consumption of beverages sweetened with high-fructose corn syrup (HFCS) is associated with obesity and with an increased risk of colorectal cancer. Whether HFCS contributes directly to tumorigenesis is unclear. We investigated the effects of daily oral administration of HFCS in adenomatous polyposis coli (APC) mutant mice, which are predisposed to develop intestinal tumors. The HFCS-treated mice showed a substantial increase in tumor size and tumor grade in the absence of obesity and metabolic syndrome. HFCS increased the concentrations of fructose and glucose in the intestinal lumen and serum, respectively, and the tumors transported both sugars. Within the tumors, fructose was converted to fructose-1-phosphate, leading to activation of glycolysis and increased synthesis of fatty acids that support tumor growth. These mouse studies support the hypothesis that the combination of dietary glucose and fructose, even at a moderate dose, can enhance tumorigenesis. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000462016400054 |
WOS关键词 | UNITED-STATES ; CANCER ; OBESITY ; CELLS ; SUGAR ; METABOLISM ; OVEREXPRESSION ; LOCALIZATION ; ABSORPTION ; EXPRESSION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201025 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Weill Cornell Med, Dept Med, Meyer Canc Ctr, New York, NY 10065 USA; 2.Weill Cornell Med, Div Endocrinol, Weill Dept Med, New York, NY 10065 USA; 3.Weill Cornell Med Coll, Dept Pharmacol, 1300 York Ave, New York, NY 10021 USA; 4.Weill Cornell Med, Div Infect Dis, Weill Dept Med, New York, NY 10065 USA; 5.Weill Cornell Med, Triinst Training Program Computat Biol & Med, New York, NY 10065 USA; 6.Univ Hosp Zurich, Inst Pathol & Mol Pathol, Zurich, Switzerland; 7.Icahn Sch Med Mt Sinai, Tisch Canc Inst, Dept Oncol Sci, New York, NY 10029 USA; 8.Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA; 9.Mem Sloan Kettering Canc Ctr, Dept Med Phys, New York, NY 10065 USA; 10.Duke Univ, Dept Med, Div Gastroenterol, Durham, NC 27708 USA; 11.Chonnam Natl Univ, Sch Dent, Dept Oral Pathol, Gwangju, South Korea |
推荐引用方式 GB/T 7714 | Goncalves, Marcus D.,Lu, Changyuan,Tutnauer, Jordan,et al. High-fructose corn syrup enhances intestinal tumor growth in mice[J]. SCIENCE,2019,363(6433):1345-+. |
APA | Goncalves, Marcus D..,Lu, Changyuan.,Tutnauer, Jordan.,Hartman, Travis E..,Hwang, Seo-Kyoung.,...&Yun, Jihye.(2019).High-fructose corn syrup enhances intestinal tumor growth in mice.SCIENCE,363(6433),1345-+. |
MLA | Goncalves, Marcus D.,et al."High-fructose corn syrup enhances intestinal tumor growth in mice".SCIENCE 363.6433(2019):1345-+. |
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