Parallel adaptation of rabbit populations to myxoma virus

doi:10.1126/science.aau7285

GSTDTAP > 地球科学

DOI	10.1126/science.aau7285
	Parallel adaptation of rabbit populations to myxoma virus
	Alves, Joel M.1,2,3; Carneiro, Miguel 2,4; Cheng, Jade Y.5,6,7; de Matos, Ana Lemos 8; Rahman, Masmudur M.8; Loog, Liisa 3,9; Campos, Paula F.7,10; Wales, Nathan 7,11,12; Eriksson, Anders 13; Manica, Andrea 14; Strive, Tanja 15,16; Graham, Stephen C.17; Afonso, Sandra 2; Bell, Diana J.18; Belmont, Laura 8; Day, Jonathan P.1; Fuller, Susan J.19; Marchandeau, Stephane 20; Palmer, William J.21,22; Queney, Guillaume 23; Surridge, Alison K.18; Vieira, Filipe G.7; McFadden, Grant 8; Nielsen, Rasmus 5,6,7; Gilbert, M. Thomas P.7,24; Esteves, Pedro J.2,25; Ferrand, Nuno 2,4,26; Jiggins, Francis M.1
	2019-03-22
发表期刊	SCIENCE
ISSN	0036-8075
EISSN	1095-9203
出版年	2019
卷号	363 期号:6433 页码:1319-+
文章类型	Article
语种	英语
国家	England; Portugal; USA; Denmark; Australia; France; Norway; South Africa
英文摘要	In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favoring the same alleles in Australia, France, and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased the protein's antiviral effect.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000462016400048
WOS关键词	WILD RABBITS ; RECEPTOR ; DISEASE ; DNA ; PROTEINS ; ACTIVATION ; RESISTANCE ; AUSTRALIA ; EVOLUTION ; SELECTION
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/201023
专题	地球科学资源环境科学气候变化
作者单位	1.Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England; 2.Univ Porto, InBIO Lab Associado, Ctr Invest Biodiversidade & Recursos Genet, CIBIO, P-4485661 Vairao, Portugal; 3.Univ Oxford, Palaeogen & Bioarchaeol Res Network, Res Lab Archaeol & Hist Art, Dyson Perrins Bldg,South Parks Rd, Oxford OX1 3QY, England; 4.Univ Porto, Fac Ciencias, Dept Biol, P-4169007 Porto, Portugal; 5.Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA; 6.Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA; 7.Univ Copenhagen, Ctr GeoGenet, Nat Hist Museum Denmark, DK-1350 Copenhagen, Denmark; 8.Arizona State Univ, Ctr Immunotherapy Vaccines & Virotherapy, Biodesign Inst, Tempe, AZ 85287 USA; 9.Univ Manchester, Manchester Inst Biotechnol, Sch Earth & Environm Sci, Manchester M1 7DN, Lancs, England; 10.Univ Porto, Interdisciplinary Ctr Marine & Environm Res, CIIMAR, Ave Gen Norton Matos S-N, P-4450208 Matosinhos, Portugal; 11.Univ Calif Berkeley, Dept Plant & Microbial Biol, 111 Koshland Hall, Berkeley, CA 94720 USA; 12.Univ York, Dept Archaeol, York YO1 7EP, N Yorkshire, England; 13.Kings Coll London, Dept Med & Mol Genet, London SE1 9RT, England; 14.Univ Cambridge, Dept Zool, Downing St, Cambridge CB2 3EJ, England; 15.Commonwealth Sci & Ind Res Org, Hlth Biosecur, Canberra, ACT 2601, Australia; 16.Univ Canberra, Ctr Invas Species Solut, Bruce, ACT 2601, Australia; 17.Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England; 18.Univ East Anglia, Sch Biol Sci, Ctr Ecol Evolut & Conservat, Norwich NR4 7TJ, Norfolk, England; 19.Queensland Univ Technol, Sci & Engn Fac, Sch Earth Environm & Biol Sci, Brisbane, Qld, Australia; 20.Off Natl Chasse & Faune Sauvage, Nantes, France; 21.Univ Calif Davis, Genome Ctr, Davis, CA 95616 USA; 22.Univ Calif Davis, Dept Plant Sci, Davis, CA 95616 USA; 23.ANTAGENE, Wildlife Genet Lab, Lyon, France; 24.Univ Museum, Norwegian Univ Sci & Technol, N-7491 Trondheim, Norway; 25.Inst Invest Formacao & Avancada Ciencias & Tecnol, Gandra, Portugal; 26.Univ Johannesburg, Fac Sci, Dept Zool, ZA-2006 Auckland Pk, South Africa
推荐引用方式 GB/T 7714	Alves, Joel M.,Carneiro, Miguel,Cheng, Jade Y.,et al. Parallel adaptation of rabbit populations to myxoma virus[J]. SCIENCE,2019,363(6433):1319-+.
APA	Alves, Joel M..,Carneiro, Miguel.,Cheng, Jade Y..,de Matos, Ana Lemos.,Rahman, Masmudur M..,...&Jiggins, Francis M..(2019).Parallel adaptation of rabbit populations to myxoma virus.SCIENCE,363(6433),1319-+.
MLA	Alves, Joel M.,et al."Parallel adaptation of rabbit populations to myxoma virus".SCIENCE 363.6433(2019):1319-+.