Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aau5870 |
Hypoxia induces rapid changes to histone methylation and reprograms chromatin | |
Batie, Michael1,2; Frost, Julianty1; Frost, Mark1; Wilson, James W.1; Schofield, Pieta2,3; Rocha, Sonia1,2 | |
2019-03-15 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 363期号:6432页码:1222-+ |
文章类型 | Article |
语种 | 英语 |
国家 | England; Scotland |
英文摘要 | Oxygen is essential for the life of most multicellular organisms. Cells possess enzymes called molecular dioxygenases that depend on oxygen for activity. A subclass of molecular dioxygenases is the histone demethylase enzymes, which are characterized by the presence of a Jumanji-C (JmjC) domain. Hypoxia can alter chromatin, but whether this is a direct effect on JmjC-histone demethylases or due to other mechanisms is unknown. Here, we report that hypoxia induces a rapid and hypoxia-inducible factor-independent induction of histone methylation in a range of human cultured cells. Genomic locations of histone-3 lysine-4 trimethylation (H3K4me3) and H3K36me3 after a brief exposure of cultured cells to hypoxia predict the cell's transcriptional response several hours later. We show that inactivation of one of the JmjC-containing enzymes, lysine demethylase 5A (KDM5A), mimics hypoxia-induced cellular responses. These results demonstrate that oxygen sensing by chromatin occurs via JmjC-histone demethylase inhibition. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000461329000050 |
WOS关键词 | R/BIOCONDUCTOR PACKAGE ; GENE-EXPRESSION ; CELL-TYPES ; IDENTIFICATION ; GENERATION ; ALIGNMENT ; ACCURATE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200971 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Liverpool, Dept Biochem, Inst Integrat Biol, Biosci Bldg,Crown St, Liverpool L69 7ZB, Merseyside, England; 2.Univ Dundee, Ctr Gene Regulat & Express, Sch Life Sci, Dow St, Dundee DD1 5EH, Scotland; 3.Univ Manchester, Computat Biol Support, CRUK Manchester Inst, Alderley Pk, Macclesfield SK10 4TG, Cheshire, England |
推荐引用方式 GB/T 7714 | Batie, Michael,Frost, Julianty,Frost, Mark,et al. Hypoxia induces rapid changes to histone methylation and reprograms chromatin[J]. SCIENCE,2019,363(6432):1222-+. |
APA | Batie, Michael,Frost, Julianty,Frost, Mark,Wilson, James W.,Schofield, Pieta,&Rocha, Sonia.(2019).Hypoxia induces rapid changes to histone methylation and reprograms chromatin.SCIENCE,363(6432),1222-+. |
MLA | Batie, Michael,et al."Hypoxia induces rapid changes to histone methylation and reprograms chromatin".SCIENCE 363.6432(2019):1222-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论