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DOI | 10.1126/science.aau6173 |
Acoel genome reveals the regulatory landscape of whole-body regeneration | |
Gehrke, Andrew R.1; Neverett, Emily1; Luo, Yi-Jyun1; Brandt, Alexander2; Ricci, Lorenzo1; Hulett, Ryan E.1; Gompers, Annika1; Ruby, J. Graham3; Rokhsar, Daniel S.4; Reddien, Peter W.5,6; Srivastava, Mansi1,7 | |
2019-03-15 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 363期号:6432页码:1191-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Whole-body regeneration is accompanied by complex transcriptomic changes, yet the chromatin regulatory landscapes that mediate this dynamic response remain unexplored. To decipher the regulatory logic that orchestrates regeneration, we sequenced the genome of the acoel worm Hofstenia miamia, a highly regenerative member of the sister lineage of other bilaterians. Epigenomic profiling revealed thousands of regeneration-responsive chromatin regions and identified dynamically bound transcription factor motifs, with the early growth response (EGR) binding site as the most variably accessible during Hofstenia regeneration. Combining egr inhibition with chromatin profiling suggests that Egr functions as a pioneer factor to directly regulate early wound-induced genes. The genetic connections inferred by this approach allowed the construction of a gene regulatory network for whole-body regeneration, enabling genomics-based comparisons of regeneration across species. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000461329000041 |
WOS关键词 | PIONEER TRANSCRIPTION FACTORS ; HEAD ; MODULATION ; ACTIVATION ; CHROMATIN ; NOTUM ; WNT |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200970 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Harvard Univ, Dept Organism & Evolutionary Biol, Cambridge, MA 02138 USA; 2.Univ Calif Berkeley, Dept Chem, Berkeley, CA 94703 USA; 3.Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA; 4.Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94703 USA; 5.MIT, Whitehead Inst Biomed Res, Howard Hughes Med Inst, Cambridge, MA 02138 USA; 6.MIT, Dept Biol, Cambridge, MA 02138 USA; 7.Harvard Univ, Museum Comparat Zool, Cambridge, MA 02138 USA |
推荐引用方式 GB/T 7714 | Gehrke, Andrew R.,Neverett, Emily,Luo, Yi-Jyun,et al. Acoel genome reveals the regulatory landscape of whole-body regeneration[J]. SCIENCE,2019,363(6432):1191-+. |
APA | Gehrke, Andrew R..,Neverett, Emily.,Luo, Yi-Jyun.,Brandt, Alexander.,Ricci, Lorenzo.,...&Srivastava, Mansi.(2019).Acoel genome reveals the regulatory landscape of whole-body regeneration.SCIENCE,363(6432),1191-+. |
MLA | Gehrke, Andrew R.,et al."Acoel genome reveals the regulatory landscape of whole-body regeneration".SCIENCE 363.6432(2019):1191-+. |
条目包含的文件 | 条目无相关文件。 |
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