Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aaw4153 |
Ushering in the next generation of precision trials for pediatric cancer | |
DuBois, Steven G.1,2,3; Corson, Laura B.1,2; Stegmaier, Kimberly1,2,3; Janeway, Katherine A.1,2,3 | |
2019-03-15 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 363期号:6432页码:1175-1181 |
文章类型 | Review |
语种 | 英语 |
国家 | USA |
英文摘要 | Cancer treatment decisions are increasingly based on the genomic profile of the patient's tumor, a strategy called "precision oncology." Over the past few years, a growing number of clinical trials and case reports have provided evidence that precision oncology is an effective approach for at least some children with cancer. Here, we review key factors influencing pediatric drug development in the era of precision oncology. We describe an emerging regulatory framework that is accelerating the pace of clinical trials in children as well as design challenges that are specific to trials that involve young cancer patients. Last, we discuss new drug development approaches for pediatric cancers whose growth relies on proteins that are difficult to target therapeutically, such as transcription factors. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000461329000038 |
WOS关键词 | INHIBITION ; THERAPY ; DABRAFENIB ; TRAMETINIB ; LANDSCAPE ; MEDICINE ; CEREBLON ; LEUKEMIA ; SYNERGY ; GENOME |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200959 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Harvard Med Sch, Dana Farber Canc Inst, Boston, MA 02215 USA; 2.Harvard Med Sch, Dana Farber Boston Childrens Canc & Blood Disorde, Boston, MA 02215 USA; 3.Harvard Med Sch, Dept Pediat, Boston, MA 02215 USA |
推荐引用方式 GB/T 7714 | DuBois, Steven G.,Corson, Laura B.,Stegmaier, Kimberly,et al. Ushering in the next generation of precision trials for pediatric cancer[J]. SCIENCE,2019,363(6432):1175-1181. |
APA | DuBois, Steven G.,Corson, Laura B.,Stegmaier, Kimberly,&Janeway, Katherine A..(2019).Ushering in the next generation of precision trials for pediatric cancer.SCIENCE,363(6432),1175-1181. |
MLA | DuBois, Steven G.,et al."Ushering in the next generation of precision trials for pediatric cancer".SCIENCE 363.6432(2019):1175-1181. |
条目包含的文件 | 条目无相关文件。 |
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