Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aat8657 |
cGAS in action: Expanding roles in immunity and inflammation | |
Ablasser, Andrea1; Chen, Zhijian J.2 | |
2019-03-08 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 363期号:6431页码:1055-+ |
文章类型 | Review |
语种 | 英语 |
国家 | Switzerland; USA |
英文摘要 | DNA is highly immunogenic. It represents a key pathogen-associated molecular pattern (PAMP) during infection. Host DNA can, however, also act as a danger-associated molecular pattern (DAMP) and elicit strong inflammatory responses. The cGAS-STING pathway has emerged as a major pathway that detects intracellular DNA. Here, we highlight recent advances on how cGAS and STING mediate inflammatory responses and how these are regulated, allowing cells to readily respond to infections and noxious agents while avoiding the inappropriate sensing of self-DNA. A particular focus is placed on the role of cGAS in the context of sterile inflammatory conditions. Manipulating cGAS or STING may open the door for new therapeutic strategies for the treatment of acute and chronic inflammation relevant to many human diseases. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000460750100034 |
WOS关键词 | CYCLIC GMP-AMP ; AICARDI-GOUTIERES-SYNDROME ; ENDOPLASMIC-RETICULUM STRESS ; CGAS/STING-DEPENDENT INNATE ; DNA SENSOR ; ENDOGENOUS 2ND-MESSENGER ; EXONUCLEASE TREX1 ; I INTERFERONS ; ACTIVATION ; CELLS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200925 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Ecole Polytech Fed Lausanne, Global Hlth Inst, CH-1015 Lausanne, Switzerland; 2.Univ Texas Southwestern Med Ctr Dallas, Howard Hughes Med Inst, Dept Mol Biol, Ctr Inflammat Res, Dallas, TX 75390 USA |
推荐引用方式 GB/T 7714 | Ablasser, Andrea,Chen, Zhijian J.. cGAS in action: Expanding roles in immunity and inflammation[J]. SCIENCE,2019,363(6431):1055-+. |
APA | Ablasser, Andrea,&Chen, Zhijian J..(2019).cGAS in action: Expanding roles in immunity and inflammation.SCIENCE,363(6431),1055-+. |
MLA | Ablasser, Andrea,et al."cGAS in action: Expanding roles in immunity and inflammation".SCIENCE 363.6431(2019):1055-+. |
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