Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aau3903 |
Direct stimulation of NADP(+) synthesis through Akt-mediated phosphorylation of NAD kinase | |
Hoxhaj, Gerta1; Ben-Sahra, Issam2; Lockwood, Sophie E.1; Timson, Rebecca C.1; Byles, Vanessa1; Henning, Graham T.1; Gao, Peng3; Selfors, Laura M.4; Asara, John M.5; Manning, Brendan D.1 | |
2019-03-08 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 363期号:6431页码:1088-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Nicotinamide adenine dinucleotide phosphate (NADP(+)) is essential for producing NADPH, the primary cofactor for reductive metabolism. We find that growth factor signaling through the phosphoinositide 3-kinase (PI3K)-Akt pathway induces acute synthesis of NADP(+) and NADPH. Akt phosphorylates NAD kinase (NADK), the sole cytosolic enzyme that catalyzes the synthesis of NADP(+) from NAD(+) (the oxidized form of NADH), on three serine residues (Ser44, Ser46, and Ser48) within an amino-terminal domain. This phosphorylation stimulates NADK activity both in cells and directly in vitro, thereby increasing NADP(+) production. A rare isoform of NADK (isoform 3) lacking this regulatory region exhibits constitutively increased activity. These data indicate that Akt-mediated phosphorylation of NADK stimulates its activity to increase NADP(+) production through relief of an autoinhibitory function inherent to its amino terminus. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000460750100048 |
WOS关键词 | BIOSYNTHESIS ; MTOR |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200924 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Harvard TH Chan Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA; 2.Northwestern Univ, Dept Biochem & Mol Genet, Feinberg Sch Med, Chicago, IL 60611 USA; 3.Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Metabol Core Facil, Chicago, IL 60611 USA; 4.Harvard Med Sch, Dept Cell Biol, Boston, MA 02115 USA; 5.Beth Israel Deaconess Med Ctr, Mass Spectrometry Core, Boston, MA 02215 USA |
推荐引用方式 GB/T 7714 | Hoxhaj, Gerta,Ben-Sahra, Issam,Lockwood, Sophie E.,et al. Direct stimulation of NADP(+) synthesis through Akt-mediated phosphorylation of NAD kinase[J]. SCIENCE,2019,363(6431):1088-+. |
APA | Hoxhaj, Gerta.,Ben-Sahra, Issam.,Lockwood, Sophie E..,Timson, Rebecca C..,Byles, Vanessa.,...&Manning, Brendan D..(2019).Direct stimulation of NADP(+) synthesis through Akt-mediated phosphorylation of NAD kinase.SCIENCE,363(6431),1088-+. |
MLA | Hoxhaj, Gerta,et al."Direct stimulation of NADP(+) synthesis through Akt-mediated phosphorylation of NAD kinase".SCIENCE 363.6431(2019):1088-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论