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DOI | 10.1126/science.aat5053 |
Glutamate signaling at cytoneme synapses | |
Huang, Hai; Liu, Songmei; Kornberg, Thomas B. | |
2019-03-01 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 363期号:6430页码:948-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | We investigated the roles of components of neuronal synapses for development of the Drosophila air sac primordium (ASP). The ASP, an epithelial tube, extends specialized signaling filopodia called cytonemes that take up signals such as Dpp (Decapentaplegic, a homolog of the vertebrate bone morphogenetic protein) from the wing imaginal disc. Dpp signaling in the ASP was compromised if disc cells lacked Synaptobrevin and Synaptotagmin-1 (which function in vesicle transport at neuronal synapses), the glutamate transporter, and a voltage-gated calcium channel, or if ASP cells lacked Synaptotagmin-4 or the glutamate receptor GluRII. Transient elevations of intracellular calcium in ASP cytonemes correlate with signaling activity. Calcium transients in ASP cells depend on GluRII, are activated by L-glutamate and by stimulation of an optogenetic ion channel expressed in the wing disc, and are inhibited by EGTA and by the GluR inhibitor NASPM (1-naphthylacetyl spermine trihydrochloride). Activation of GluRII is essential but not sufficient for signaling. Cytoneme-mediated signaling is glutamatergic. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000460194200039 |
WOS关键词 | NEUROTRANSMITTER RELEASE ; DROSOPHILA ; CHANNELS ; RECEPTORS ; HEDGEHOG ; RECONSTITUTION ; CACOPHONY ; GRADIENT ; NEURONS ; PROTEIN |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200871 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA |
推荐引用方式 GB/T 7714 | Huang, Hai,Liu, Songmei,Kornberg, Thomas B.. Glutamate signaling at cytoneme synapses[J]. SCIENCE,2019,363(6430):948-+. |
APA | Huang, Hai,Liu, Songmei,&Kornberg, Thomas B..(2019).Glutamate signaling at cytoneme synapses.SCIENCE,363(6430),948-+. |
MLA | Huang, Hai,et al."Glutamate signaling at cytoneme synapses".SCIENCE 363.6430(2019):948-+. |
条目包含的文件 | 条目无相关文件。 |
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