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DOI | 10.1126/science.aat7186 |
Epithelial endoplasmic reticulum stress orchestrates a protective IgA response | |
Grootjans, Joep1,2,3; Krupka, Niklas1,4; Hosomi, Shuhei1,5; Matute, Juan D.1,6; Hanley, Thomas1; Saveljeva, Svetlana7; Gensollen, Thomas1; Heijmans, Jarom8; Li, Hai4; Limenitakis, Julien P.4; Ganal-Vonarburg, Stephanie C.4; Suo, Shengbao9; Luoma, Adrienne M.10; Shimodaira, Yosuke11; Duan, Jinzhi1; Shih, David Q.11; Conner, Margaret E.12; Glickman, Jonathan N.13; Fuhler, Gwenny M.14; Palm, Noah W.15; de Zoete, Marcel R.16; van der Woude, C. Janneke14; Yuan, Guo-Cheng9; Wucherpfennig, Kai W.10; Targan, Stephan R.11; Rosenstiel, Philip17; Flavell, Richard A.15,18; McCoy, Kathy D.19; Macpherson, Andrew J.4; Kaser, Arthur7; Blumberg, Richard S.1 | |
2019-03-01 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 363期号:6430页码:993-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Netherlands; Switzerland; Japan; England; Germany; Canada |
英文摘要 | Immunoglobulin A (IgA) is the major secretory immunoglobulin isotype found at mucosal surfaces, where it regulates microbial commensalism and excludes luminal factors from contacting intestinal epithelial cells (IECs). IgA is induced by both T cell-dependent and -independent (TI) pathways. However, little is known about TI regulation. We report that IEC endoplasmic reticulum (ER) stress induces a polyreactive IgA response, which is protective against enteric inflammation. IEC ER stress causes TI and microbiotaindependent expansion and activation of peritoneal B1b cells, which culminates in increased lamina propria and luminal IgA. Increased numbers of IgA-producing plasma cells were observed in healthy humans with defective autophagy, who are known to exhibit IEC ER stress. Upon ER stress, IECs communicate signals to the peritoneum that induce a barrier-protective TI IgA response. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000460194200049 |
WOS关键词 | UNFOLDED PROTEIN RESPONSE ; SECRETORY ANTIBODIES ; PANETH CELLS ; ER STRESS ; B-CELLS ; EXPRESSION ; INFLAMMATION ; GENERATION ; DEFICIENT ; BACTERIA |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200870 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Harvard Med Sch, Div Gastroenterol, Dept Med, Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA; 2.Univ Amsterdam, Dept Gastroenterol & Hepatol, Amsterdam Univ Med Ctr, Meibergdreef 9, Amsterdam, Netherlands; 3.Tygat Inst Liver & Intestinal Res, Meibergdreef 9, Amsterdam, Netherlands; 4.Univ Bern, Maurice Muller Labs DBMR, Univ Klin Viszerale Chirurg & Med Inselspital, Murtenstr 35, CH-3010 Bern, Switzerland; 5.Osaka City Univ, Grad Sch Med, Dept Gastroenterol, Abeno Ku, 1-4-3 Asahi Machi, Osaka 5458585, Japan; 6.Harvard Med Sch, Div Neonatol, Dept Pediat, Massachusetts Gen Hosp, Boston, MA 02114 USA; 7.Univ Cambridge, Div Gastroenterol & Hepatol, Dept Med, Cambridge CB2 0QQ, England; 8.Univ Amsterdam, Dept Internal Med, Tygat Inst Liver & Intestinal Res, Amsterdam Univ Med Ctr, Meibergdreef 9, Amsterdam, Netherlands; 9.Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02215 USA; 10.Dana Farber Canc Inst, Dept Canc Immunol & Virol, 450 Brookline Ave, Boston, MA 02215 USA; 11.Cedars Sinai Med Ctr, F Widjaja Fdn, Inflammatory Bowel & Immunobiol Res Inst, Los Angeles, CA 90048 USA; 12.Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA; 13.Harvard Med Sch, Dept Pathol, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA; 14.Erasmus MC, Dept Gastroenterol & Hepatol, Univ Med Ctr, Rotterdam, Netherlands; 15.Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06519 USA; 16.Univ Utrecht, Dept Infect Dis & Immunol, Fac Vet Med, Utrecht, Netherlands; 17.Christian Albrechts Univ Kiel, Inst Clin Mol Biol, Rosalind Franklin Str 12, D-24105 Kiel, Germany; 18.Yale Univ, Howard Hughes Med Inst, Sch Med, New Haven, CT 06519 USA; 19.Univ Calgary, Dept Physiol & Pharmacol, Calgary, AB, Canada |
推荐引用方式 GB/T 7714 | Grootjans, Joep,Krupka, Niklas,Hosomi, Shuhei,et al. Epithelial endoplasmic reticulum stress orchestrates a protective IgA response[J]. SCIENCE,2019,363(6430):993-+. |
APA | Grootjans, Joep.,Krupka, Niklas.,Hosomi, Shuhei.,Matute, Juan D..,Hanley, Thomas.,...&Blumberg, Richard S..(2019).Epithelial endoplasmic reticulum stress orchestrates a protective IgA response.SCIENCE,363(6430),993-+. |
MLA | Grootjans, Joep,et al."Epithelial endoplasmic reticulum stress orchestrates a protective IgA response".SCIENCE 363.6430(2019):993-+. |
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