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DOI | 10.1126/science.aau0364 |
Catalytic reductive [4+1]-cycloadditions of vinylidenes and dienes | |
Zhou, You-Yun; Uyeda, Christopher | |
2019-02-22 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 363期号:6429页码:857-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Cycloaddition reactions provide direct and convergent routes to cycloalkanes, making them valuable targets for the development of synthetic methods. Whereas six-membered rings are readily accessible from Diels-Alder reactions, cycloadditions that generate five-membered rings are comparatively limited in scope. Here, we report that dinickel complexes catalyze [4 + 1]-cycloaddition reactions of 1,3-dienes. The C-1 partner is a vinylidene equivalent generated from the reductive activation of a 1,1-dichloroalkene in the presence of stoichiometric zinc. Intermolecular and intramolecular variants of the reaction are described, and high levels of asymmetric induction are achieved in the intramolecular cycloadditions using a C-2-symmetric chiral ligand that stabilizes a metal-metal bond. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000459387100041 |
WOS关键词 | 4+1 CYCLOADDITION ; STEREOSELECTIVE-SYNTHESIS ; COMPLEXES ; 1,3-DIENES ; 1,4-ADDITION ; DERIVATIVES ; METHYLENE ; CARBENES ; REAGENTS ; STATES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200821 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA |
推荐引用方式 GB/T 7714 | Zhou, You-Yun,Uyeda, Christopher. Catalytic reductive [4+1]-cycloadditions of vinylidenes and dienes[J]. SCIENCE,2019,363(6429):857-+. |
APA | Zhou, You-Yun,&Uyeda, Christopher.(2019).Catalytic reductive [4+1]-cycloadditions of vinylidenes and dienes.SCIENCE,363(6429),857-+. |
MLA | Zhou, You-Yun,et al."Catalytic reductive [4+1]-cycloadditions of vinylidenes and dienes".SCIENCE 363.6429(2019):857-+. |
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