How a circularized tmRNA moves through the ribosome

doi:10.1126/science.aav9370

GSTDTAP > 地球科学

DOI	10.1126/science.aav9370
	How a circularized tmRNA moves through the ribosome
	Rae, Christopher D.; Gordiyenko, Yuliya; Ramakrishnan, V.
	2019-02-15
发表期刊	SCIENCE
ISSN	0036-8075
EISSN	1095-9203
出版年	2019
卷号	363 期号:6428 页码:740-+
文章类型	Article
语种	英语
国家	England
英文摘要	During trans-translation, transfer-messenger RNA (tmRNA) and small protein B (SmpB) together rescue ribosomes stalled on a truncated mRNA and tag the nascent polypeptide for degradation. We used cryo-electron microscopy to determine the structures of three key states of the tmRNA-SmpB-ribosome complex during trans translation at resolutions of 3.7 to 4.4 angstroms. The results show how tmRNA and SmpB act specifically on stalled ribosomes and how the circularized complexmoves through the ribosome, enabling translation to switch from the old defective message to the reading frame on tmRNA.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000458874100033
WOS关键词	SMALL PROTEIN-B ; MESSENGER-RNA ; TRANS-TRANSLATION ; TAGGING ACTIVITY ; STRUCTURAL BASIS ; 10SA RNA ; SMPB ; RESCUE ; SYSTEM ; ACTIVATION
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
引用统计	被引频次：27[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/200759
专题	地球科学资源环境科学气候变化
作者单位	MRC, Mol Biol Lab, Francis Crick Ave, Cambridge, England
推荐引用方式 GB/T 7714	Rae, Christopher D.,Gordiyenko, Yuliya,Ramakrishnan, V.. How a circularized tmRNA moves through the ribosome[J]. SCIENCE,2019,363(6428):740-+.
APA	Rae, Christopher D.,Gordiyenko, Yuliya,&Ramakrishnan, V..(2019).How a circularized tmRNA moves through the ribosome.SCIENCE,363(6428),740-+.
MLA	Rae, Christopher D.,et al."How a circularized tmRNA moves through the ribosome".SCIENCE 363.6428(2019):740-+.