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DOI | 10.1126/science.aat9120 |
Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers | |
Tokatlian, Talar1; Read, Benjamin J.1,2,3; Jones, Christopher A.1; Kulp, Daniel W.4,5,6; Menis, Sergey5,6; Chang, Jason Y. H.1; Steichen, Jon M.5,6; Kumari, Sudha1; Allen, Joel D.7,8; Dane, Eric L.1; Liguori, Alessia6,9; Sangesland, Maya10,11; Lingwood, Daniel10,11; Crispin, Max5,6,7,8,9; Schief, William R.5,6,9,10,11; Irvine, Darrell J.1,6,10,11,12,13,14 | |
2019-02-08 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 363期号:6427页码:649-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; England |
英文摘要 | In vaccine design, antigens are often arrayed in a multivalent nanoparticle form, but in vivo mechanisms underlying the enhanced immunity elicited by such vaccines remain poorly understood. We compared the fates of two different heavily glycosylated HIV antigens, a gp120-derived mini-protein and a large, stabilized envelope trimer, in protein nanoparticle or "free" forms after primary immunization. Unlike monomeric antigens, nanoparticles were rapidly shuttled to the follicular dendritic cell (FDC) network and then concentrated in germinal centers in a complement-, mannose-binding lectin (MBL)-, and immunogen glycan-dependent manner. Loss of FDC localization in MBL-deficient mice or via immunogen deglycosylation significantly affected antibody responses. These findings identify an innate immune-mediated recognition pathway promoting antibody responses to particulate antigens, with broad implications for humoral immunity and vaccine design. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000458114200053 |
WOS关键词 | FOLLICULAR HELPER-CELLS ; MANNOSE-BINDING LECTIN ; SUBCAPSULAR SINUS ; RATIONAL DESIGN ; VACCINE ; ANTIGEN ; PRECURSORS ; ANTIBODIES ; TRANSPORT ; ARRAY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200723 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA; 2.Harvard Univ, Hlth Sci & Technol, Cambridge, MA 02139 USA; 3.MIT, Cambridge, MA 02139 USA; 4.Wistar Inst Anat & Biol, Vaccine & Immunotherapy Ctr, 3601 Spruce St, Philadelphia, PA 19104 USA; 5.Scripps Res Inst, Int AIDS Vaccine Initiat Neutralizing Antibody Ct, La Jolla, CA 92037 USA; 6.Scripps Res Inst, Ctr HIV AIDS Vaccine Immunol & Immunogen Discover, La Jolla, CA 92037 USA; 7.Univ Southampton, Biol Sci, Southampton SO17 1BJ, Hants, England; 8.Univ Southampton, Inst Life Sci, Southampton SO17 1BJ, Hants, England; 9.Scripps Res Inst, Immunol & Microbial Sci, La Jolla, CA 92037 USA; 10.MIT, Ragon Inst, Massachusetts Gen Hosp, 77 Massachusetts Ave, Cambridge, MA 02139 USA; 11.Harvard Univ, Cambridge, MA 02139 USA; 12.MIT, Dept Biol Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA; 13.MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA; 14.Howard Hughes Med Inst, Chevy Chase, MD 20815 USA |
推荐引用方式 GB/T 7714 | Tokatlian, Talar,Read, Benjamin J.,Jones, Christopher A.,et al. Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers[J]. SCIENCE,2019,363(6427):649-+. |
APA | Tokatlian, Talar.,Read, Benjamin J..,Jones, Christopher A..,Kulp, Daniel W..,Menis, Sergey.,...&Irvine, Darrell J..(2019).Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers.SCIENCE,363(6427),649-+. |
MLA | Tokatlian, Talar,et al."Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers".SCIENCE 363.6427(2019):649-+. |
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