Choline acetyltransferase-expressing T cells are required to control chronic viral infection

doi:10.1126/science.aau9072

GSTDTAP > 地球科学

DOI	10.1126/science.aau9072
	Choline acetyltransferase-expressing T cells are required to control chronic viral infection
	Cox, Maureen A.1; Duncan, Gordon S.1; Lin, Gloria H. Y.1,13; Steinberg, Benjamin E.1,2,14; Yu, Lisa X.3; Brenner, Dirk 1,4,5,6; Buckler, Luke N.1; Elia, Andrew J.1; Wakeham, Andrew C.1; Nieman, Brian 3,7,8; Dominguez-Brauer, Carmen 1; Elford, Alisha R.1; Gill, Kyle T.1; Kubli, Shawn P.1; Haight, Jillian 1; Berger, Thorsten 1; Ohashi, Pamela S.1,9; Tracey, Kevin J.10; Olofsson, Peder S.10,11; Mak, Tak W.1,7,8,9,12
	2019-02-08
发表期刊	SCIENCE
ISSN	0036-8075
EISSN	1095-9203
出版年	2019
卷号	363 期号:6427 页码:639-+
文章类型	Article
语种	英语
国家	Canada; Luxembourg; Denmark; USA; Sweden; Peoples R China
英文摘要	Although widely studied as a neurotransmitter, T cell-derived acetylcholine (ACh) has recently been reported to play an important role in regulating immunity. However, the role of lymphocyte-derived ACh in viral infection is unknown. Here, we show that the enzyme choline acetyltransferase (ChAT), which catalyzes the rate-limiting step of ACh production, is robustly induced in both CD4(+) and CD8(+) T cells during lymphocytic choriomeningitis virus (LCMV) infection in an IL-21-dependent manner. Deletion of Chat within the T cell compartment in mice ablated vasodilation in response to infection, impaired the migration of antiviral T cells into infected tissues, and ultimately compromised the control of chronic LCMV clone 13 infection. Our results reveal a genetic proof of function for ChAT in T cells during viral infection and identify a pathway of T cell migration that sustains antiviral immunity.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000458114200051
WOS关键词	IL-21 ; EFFECTOR
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/200715
专题	地球科学资源环境科学气候变化
作者单位	1.Univ Hlth Network, Campbell Family Inst Breast Canc Res, Princess Margaret Canc Ctr, Toronto, ON M5G 2M9, Canada; 2.Univ Toronto, Dept Anesthesia, Toronto, ON M5G 1E2, Canada; 3.Hosp Sick Children, Mouse Imaging Ctr, Toronto, ON M5T 3H7, Canada; 4.Luxembourg Inst Hlth, Dept Infect & Immun, L-4354 Esch Sur Alzette, Luxembourg; 5.Univ Southern Denmark, Odense Univ Hosp, ORCA, Dept Dermatol, Odense, Denmark; 6.Univ Southern Denmark, Odense Univ Hosp, Allergy Ctr, Odense, Denmark; 7.Univ Toronto, Ontario Inst Canc Res, Toronto, ON M5G 2C1, Canada; 8.Univ Toronto, Dept Med Biophys, Toronto, ON M5G 2C1, Canada; 9.Univ Toronto, Dept Immunol, Toronto, ON M5G 2C1, Canada; 10.Feinstein Inst Med Res, Lab Biomed Sci, Manhasset, NY 11030 USA; 11.Karolinska Inst, Karolinska Univ Hosp, Dept Med, Ctr Bioelect Med, S-17176 Stockholm, Sweden; 12.Univ Hong Kong, Dept Pathol, Hong Kong, Peoples R China; 13.Trillium Therapeut Inc, Mississauga, ON L5L 1J9, Canada; 14.Hosp Sick Children, Dept Anesthesia & Pain Med, Toronto, ON M5G 1X8, Canada
推荐引用方式 GB/T 7714	Cox, Maureen A.,Duncan, Gordon S.,Lin, Gloria H. Y.,et al. Choline acetyltransferase-expressing T cells are required to control chronic viral infection[J]. SCIENCE,2019,363(6427):639-+.
APA	Cox, Maureen A..,Duncan, Gordon S..,Lin, Gloria H. Y..,Steinberg, Benjamin E..,Yu, Lisa X..,...&Mak, Tak W..(2019).Choline acetyltransferase-expressing T cells are required to control chronic viral infection.SCIENCE,363(6427),639-+.
MLA	Cox, Maureen A.,et al."Choline acetyltransferase-expressing T cells are required to control chronic viral infection".SCIENCE 363.6427(2019):639-+.