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DOI | 10.1126/science.aau8722 |
Intense threat switches dorsal raphe serotonin neurons to a paradoxical operational mode | |
Seo, Changwoo1,2; Guru, Akash1,2; Jin, Michelle1,3; Ito, Brendan1; Sleezer, Brianna J.1; Ho, Yi-Yun1,2; Wang, Elias1,4; Boada, Christina1,5; Krupa, Nicholas A.1; Kullakanda, Durgaprasad S.1; Shen, Cynthia X.1; Warden, Melissa R.1,2 | |
2019-02-01 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 363期号:6426页码:538-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Survival depends on the selection of behaviors adaptive for the current environment. For example, a mouse should run from a rapidly looming hawk but should freeze if the hawk is coasting across the sky. Although serotonin has been implicated in adaptive behavior, environmental regulation of its functional role remains poorly understood. In mice, we found that stimulation of dorsal raphe serotonin neurons suppressed movement in low- and moderate-threat environments but induced escape behavior in high-threat environments, and that movement-related dorsal raphe serotonin neural dynamics inverted in high-threat environments. Stimulation of dorsal raphe gamma-aminobutyric acid (GABA) neurons promoted movement in negative but not positive environments, and movement-related GABA neural dynamics inverted between positive and negative environments. Thus, dorsal raphe circuits switch between distinct operational modes to promote environment-specific adaptive behaviors. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000457409400052 |
WOS关键词 | DOPAMINE ; ORGANIZATION ; ACTIVATION ; PROJECTION ; DYNAMICS ; BEHAVIOR ; MOUSE ; TONE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200664 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Cornell Univ, Dept Neurobiol & Behav, Ithaca, NY 14853 USA; 2.Cornell Univ, Cornell Neurotech, Ithaca, NY 14853 USA; 3.NIDA, Neurobiol Relapse Sect, Intramural Res Program, Baltimore, MD 21224 USA; 4.Stanford Univ, Dept Elect Engn, Stanford, CA 94305 USA; 5.NYU, Sch Med, New York, NY 10016 USA |
推荐引用方式 GB/T 7714 | Seo, Changwoo,Guru, Akash,Jin, Michelle,et al. Intense threat switches dorsal raphe serotonin neurons to a paradoxical operational mode[J]. SCIENCE,2019,363(6426):538-+. |
APA | Seo, Changwoo.,Guru, Akash.,Jin, Michelle.,Ito, Brendan.,Sleezer, Brianna J..,...&Warden, Melissa R..(2019).Intense threat switches dorsal raphe serotonin neurons to a paradoxical operational mode.SCIENCE,363(6426),538-+. |
MLA | Seo, Changwoo,et al."Intense threat switches dorsal raphe serotonin neurons to a paradoxical operational mode".SCIENCE 363.6426(2019):538-+. |
条目包含的文件 | 条目无相关文件。 |
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