GSTDTAP  > 地球科学
DOI10.1126/science.aat0805
The importance of synthetic chemistry in the pharmaceutical industry
Campos, Kevin R.1; Coleman, Paul J.1; Alvarez, Juan C.1; Dreher, Spencer D.1; Garbaccio, Robert M.1; Terrett, Nicholas K.1; Tillyer, Richard D.2; Truppo, Matthew D.2; Parmee, Emma R.1
2019-01-18
发表期刊SCIENCE
ISSN0036-8075
EISSN1095-9203
出版年2019
卷号363期号:6424页码:244-+
文章类型Review
语种英语
国家USA
英文摘要

Innovations in synthetic chemistry have enabled the discovery of many breakthrough therapies that have improved human health over the past century. In the face of increasing challenges in the pharmaceutical sector, continued innovation in chemistry is required to drive the discovery of the next wave of medicines. Novel synthetic methods not only unlock access to previously unattainable chemical matter, but also inspire new concepts as to how we design and build chemical matter. We identify some of the most important recent advances in synthetic chemistry as well as opportunities at the interface with partner disciplines that are poised to transform the practice of drug discovery and development.


领域地球科学 ; 气候变化 ; 资源环境
收录类别SCI-E
WOS记录号WOS:000456140700024
WOS关键词HIGH-THROUGHPUT EXPERIMENTATION ; CARBOXYLIC-ACIDS ; NATIVE PROTEINS ; DISCOVERY ; PHOTOREDOX ; CATALYSIS ; SITE ; FUNCTIONALIZATION ; FLUORINATION ; PERFORMANCE
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/200564
专题地球科学
资源环境科学
气候变化
作者单位1.Merck & Co Inc, Global Chem, Kenilworth, NJ 07033 USA;
2.Janssen Res & Dev LLC, Spring House, PA 19477 USA
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GB/T 7714
Campos, Kevin R.,Coleman, Paul J.,Alvarez, Juan C.,et al. The importance of synthetic chemistry in the pharmaceutical industry[J]. SCIENCE,2019,363(6424):244-+.
APA Campos, Kevin R..,Coleman, Paul J..,Alvarez, Juan C..,Dreher, Spencer D..,Garbaccio, Robert M..,...&Parmee, Emma R..(2019).The importance of synthetic chemistry in the pharmaceutical industry.SCIENCE,363(6424),244-+.
MLA Campos, Kevin R.,et al."The importance of synthetic chemistry in the pharmaceutical industry".SCIENCE 363.6424(2019):244-+.
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