Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aat4104 |
Cell-autonomous clock of astrocytes drives circadian behavior in mammals | |
Brancaccio, Marco1,2; Edwards, Mathew D.1,3; Patton, Andrew P.1; Smyllie, Nicola J.1; Chesham, Johanna E.1; Maywood, Elizabeth S.1; Hastings, Michael H.1 | |
2019-01-11 | |
发表期刊 | SCIENCE
![]() |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 363期号:6423页码:187-192 |
文章类型 | Article |
语种 | 英语 |
国家 | England |
英文摘要 | Circadian (similar to 24-hour) rhythms depend on intracellular transcription-translation negative feedback loops (TTFLs). How these self-sustained cellular clocks achieve multicellular integration and thereby direct daily rhythms of behavior in animals is largely obscure. The suprachiasmatic nucleus (SCN) is the fulcrum of this pathway from gene to cell to circuit to behavior in mammals. We describe cell type-specific, functionally distinct TTFLs in neurons and astrocytes of the SCN and show that, in the absence of other cellular clocks, the cell-autonomous astrocytic TTFL alone can drive molecular oscillations in the SCN and circadian behavior in mice. Astrocytic clocks achieve this by reinstating clock gene expression and circadian function of SCN neurons via glutamatergic signals. Our results demonstrate that astrocytes can autonomously initiate and sustain complex mammalian behavior. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000455320600053 |
WOS关键词 | SUPRACHIASMATIC NUCLEUS ; TIME ; EXPRESSION ; MECHANISM ; RHYTHMS ; CRY1 |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200512 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.MRC Lab Mol Biol, Div Neurobiol, Cambridge CB2 0QH, England; 2.Imperial Coll London, Dept Med, Div Brain Sci, London W12 0NN, England; 3.SWC Neural Circuits & Behav, London W1T 4JG, England |
推荐引用方式 GB/T 7714 | Brancaccio, Marco,Edwards, Mathew D.,Patton, Andrew P.,et al. Cell-autonomous clock of astrocytes drives circadian behavior in mammals[J]. SCIENCE,2019,363(6423):187-192. |
APA | Brancaccio, Marco.,Edwards, Mathew D..,Patton, Andrew P..,Smyllie, Nicola J..,Chesham, Johanna E..,...&Hastings, Michael H..(2019).Cell-autonomous clock of astrocytes drives circadian behavior in mammals.SCIENCE,363(6423),187-192. |
MLA | Brancaccio, Marco,et al."Cell-autonomous clock of astrocytes drives circadian behavior in mammals".SCIENCE 363.6423(2019):187-192. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论