Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aau5238 |
Invertible promoters mediate bacterial phase variation, antibiotic resistance, and host adaptation in the gut | |
Jiang, Xiaofang1,2; Hall, A. Brantley2,3; Arthur, Timothy D.2; Plichta, Damian R.2,3; Covington, Christian T.2,3; Poyet, Mathilde1,2,4; Crothers, Jessica5; Moses, Peter L.6; Tolonen, Andrew C.2,3; Vlamakis, Hera2,3; Alm, Eric J.1,2,4; Xavier, Ramnik J.1,2,3,7,8,9 | |
2019-01-11 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 363期号:6423页码:181-187 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Phase variation, the reversible alternation between genetic states, enables infection by pathogens and colonization by commensals. However, the diversity of phase variation remains underexplored. We developed the PhaseFinder algorithm to quantify DNA inversion-mediated phase variation. A systematic search of 54,875 bacterial genomes identified 4686 intergenic invertible DNA regions (invertons), revealing an enrichment in host-associated bacteria. Invertons containing promoters often regulate extracellular products, underscoring the importance of surface diversity for gut colonization. We found invertons containing promoters regulating antibiotic resistance genes that shift to the ON orientation after antibiotic treatment in human metagenomic data and in vitro, thereby mitigating the cost of antibiotic resistance. We observed that the orientations of some invertons diverge after fecal microbiota transplant, potentially as a result of individual-specific selective forces. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000455320600052 |
WOS关键词 | SURFACE ARCHITECTURE ; INVERSION ; GENES ; ANNOTATION ; SWITCHES ; FITNESS ; ELEMENT |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200511 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.MIT, Ctr Microbiome Informat & Therapeut, 77 Massachusetts Ave, Cambridge, MA 02139 USA; 2.Broad Inst MIT & Harvard, Cambridge, MA 02142 USA; 3.Massachusetts Gen Hosp, Ctr Computat & Integrat Biol, Boston, MA 02114 USA; 4.MIT, Dept Biol Engn, Cambridge, MA 02142 USA; 5.Univ Vermont, Med Ctr, Dept Pathol & Lab Med, Burlington, VT 05401 USA; 6.Univ Vermont, Div Gastroenterol & Hepatol, Burlington, VT 05401 USA; 7.Massachusetts Gen Hosp, Gastrointestinal Unit, Boston, MA 02114 USA; 8.Massachusetts Gen Hosp, Ctr Study Inflammatory Bowel Dis, Boston, MA 02114 USA; 9.Harvard Med Sch, Boston, MA 02114 USA |
推荐引用方式 GB/T 7714 | Jiang, Xiaofang,Hall, A. Brantley,Arthur, Timothy D.,et al. Invertible promoters mediate bacterial phase variation, antibiotic resistance, and host adaptation in the gut[J]. SCIENCE,2019,363(6423):181-187. |
APA | Jiang, Xiaofang.,Hall, A. Brantley.,Arthur, Timothy D..,Plichta, Damian R..,Covington, Christian T..,...&Xavier, Ramnik J..(2019).Invertible promoters mediate bacterial phase variation, antibiotic resistance, and host adaptation in the gut.SCIENCE,363(6423),181-187. |
MLA | Jiang, Xiaofang,et al."Invertible promoters mediate bacterial phase variation, antibiotic resistance, and host adaptation in the gut".SCIENCE 363.6423(2019):181-187. |
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