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DOI | 10.1126/science.aan1425 |
DNA fragility in the parallel evolution of pelvic reduction in stickleback fish | |
Xie, Kathleen T.1,2,3; Wang, Guliang4; Thompson, Abbey C.1,5; Wucherpfennig, Julia I.1; Reimchen, Thomas E.6; MacColl, Andrew D. C.7; Schluter, Dolph8; Bell, Michael A.9,10; Vasquez, Karen M.4; Kingsley, David M.1,2 | |
2019-01-04 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 363期号:6422页码:81-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Canada; England |
英文摘要 | Evolution generates a remarkable breadth of living forms, but many traits evolve repeatedly, by mechanisms that are still poorly understood. A classic example of repeated evolution is the loss of pelvic hindfins in stickleback fish (Gasterosteus aculeatus). Repeated pelvic loss maps to recurrent deletions of a pelvic enhancer of the Pitx1 gene. Here, we identify molecular features contributing to these recurrent deletions. Pitx1 enhancer sequences form alternative DNA structures in vitro and increase double-strand breaks and deletions in vivo. Enhancer mutability depends on DNA replication direction and is caused by TG-dinucleotide repeats. Modeling shows that elevated mutation rates can influence evolution under demographic conditions relevant for sticklebacks and humans. DNA fragility may thus help explain why the same loci are often used repeatedly during parallel adaptive evolution. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000455315800065 |
WOS关键词 | GASTEROSTEUS-ACULEATUS ; FORMING SEQUENCES ; NATURAL-SELECTION ; HUMAN GENOME ; REPLICATION ; FIXATION ; MUTATION ; POPULATION ; ADAPTATION ; MUTANT |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200440 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Stanford Univ, Sch Med, Dept Dev Biol, Stanford, CA 94305 USA; 2.Stanford Univ, Sch Med, Howard Hughes Med Inst, Stanford, CA 94305 USA; 3.Stanford Univ, Sch Med, Dept Biochem, Stanford, CA 94305 USA; 4.Univ Texas Austin, Div Pharmacol & Toxicol, Austin, TX 78712 USA; 5.Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA; 6.Univ Victoria, Dept Biol, Victoria, BC, Canada; 7.Univ Nottingham, Sch Life Sci, Nottingham, England; 8.Univ British Columbia, Dept Zool, Vancouver, BC, Canada; 9.SUNY Stony Brook, Dept Ecol & Evolut, Stony Brook, NY 11794 USA; 10.Univ Calif Berkeley, Museum Paleontol, Berkeley, CA 94720 USA |
推荐引用方式 GB/T 7714 | Xie, Kathleen T.,Wang, Guliang,Thompson, Abbey C.,et al. DNA fragility in the parallel evolution of pelvic reduction in stickleback fish[J]. SCIENCE,2019,363(6422):81-+. |
APA | Xie, Kathleen T..,Wang, Guliang.,Thompson, Abbey C..,Wucherpfennig, Julia I..,Reimchen, Thomas E..,...&Kingsley, David M..(2019).DNA fragility in the parallel evolution of pelvic reduction in stickleback fish.SCIENCE,363(6422),81-+. |
MLA | Xie, Kathleen T.,et al."DNA fragility in the parallel evolution of pelvic reduction in stickleback fish".SCIENCE 363.6422(2019):81-+. |
条目包含的文件 | 条目无相关文件。 |
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