Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aat6720 |
Transcriptome and epigenome landscape of human cortical development modeled in organoids | |
Amiri, Anahita1; Coppola, Gianfilippo1; Scuderi, Soraya1; Wu, Feinan1; Roychowdhury, Tanmoy2; Liu, Fuchen3; Pochareddy, Sirisha3; Shin, Yurae3,4; Safi, Alexias5; Song, Lingyun5; Zhu, Ying3,6; Sousa, Andre M. M.3; Gerstein, Mark7,8,9; Crawford, Gregory E.5; Sestan, Nenad3,10; Abyzov, Alexej2; Vaccarino, Flora M.1,3,10 | |
2018-12-14 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 362期号:6420页码:1268-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; South Korea |
英文摘要 | Genes implicated in neuropsychiatric disorders are active in human fetal brain, yet difficult to study in a longitudinal fashion. We demonstrate that organoids from human pluripotent cells model cerebral cortical development on the molecular level before 16 weeks postconception. A multiomics analysis revealed differentially active genes and enhancers, with the greatest changes occurring at the transition from stem cells to progenitors. Networks of converging gene and enhancer modules were assembled into six and four global patterns of expression and activity across time. A pattern with progressive down-regulation was enriched with human-gained enhancers, suggesting their importance in early human brain development. A few convergent gene and enhancer modules were enriched in autism-associated genes and genomic variants in autistic children. The organoid model helps identify functional elements that may drive disease onset. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000452994400045 |
WOS关键词 | PLURIPOTENT STEM-CELLS ; GENE-EXPRESSION ; READ ALIGNMENT ; SENDAI-VIRUS ; HUMAN GENOME ; RISK ; CHROMATIN ; DYNAMICS ; COMMON ; RARE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200321 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Yale Univ, Child Study Ctr, New Haven, CT 06520 USA; 2.Mayo Clin, Dept Hlth Sci Res, Ctr Individualized Med, Rochester, MN 55905 USA; 3.Yale Univ, Dept Neurosci, New Haven, CT 06520 USA; 4.Natl Res Fdn Korea, Daejeon, South Korea; 5.Duke Univ, Dept Pediat, Div Med Genet, Durham, NC 27708 USA; 6.Yale Sch Publ Hlth, Dept Biostat, New Haven, CT USA; 7.Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA; 8.Yale Univ, Dept Comp Sci, POB 2158, New Haven, CT 06520 USA; 9.Yale Univ, Dept Stat & Data Sci, New Haven, CT 06520 USA; 10.Yale Univ, Kavli Inst Neurosci, New Haven, CT 06520 USA |
推荐引用方式 GB/T 7714 | Amiri, Anahita,Coppola, Gianfilippo,Scuderi, Soraya,et al. Transcriptome and epigenome landscape of human cortical development modeled in organoids[J]. SCIENCE,2018,362(6420):1268-+. |
APA | Amiri, Anahita.,Coppola, Gianfilippo.,Scuderi, Soraya.,Wu, Feinan.,Roychowdhury, Tanmoy.,...&Vaccarino, Flora M..(2018).Transcriptome and epigenome landscape of human cortical development modeled in organoids.SCIENCE,362(6420),1268-+. |
MLA | Amiri, Anahita,et al."Transcriptome and epigenome landscape of human cortical development modeled in organoids".SCIENCE 362.6420(2018):1268-+. |
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