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DOI | 10.1126/science.aau5445 |
A femtomolar-range suicide germination stimulant for the parasitic plant Striga hermonthica | |
Uraguchi, Daisuke1; Kuwata, Keiko2; Hijikata, Yuh2,3; Yamaguchi, Rie2; Imaizumi, Hanae2; Sathiyanarayanan, A. M.2; Rakers, Christin3,7; Mori, Narumi4; Akiyama, Kohki4; Irle, Stephan2,3,8,9; McCourt, Peter5; Kinoshita, Toshinori2,3; Ooi, Takashi1,2,6; Tsuchiya, Yuichiro2 | |
2018-12-14 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 362期号:6420页码:1301-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Japan; Canada; USA |
英文摘要 | The parasitic plant Striga hermonthica has been causing devastating damage to the crop production in Africa. Because Striga requires host-generated strigolactones to germinate, the identification of selective and potent strigolactone agonists could help control these noxious weeds. We developed a selective agonist, sphynolactone-7, a hybrid molecule originated from chemical screening, that contains two functional modules derived from a synthetic scaffold and a core component of strigolactones. Cooperative action of these modules in the activation of a high-affinity strigolactone receptor ShHTL7 allows sphynolactone-7 to provoke Striga germination with potency in the femtomolar range. We demonstrate that sphynolactone-7 is effective for reducing Striga parasitism without impinging on host strigolactone-related processes. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000452994400055 |
WOS关键词 | STRIGOLACTONE RECEPTORS ; ARABIDOPSIS ; PERCEPTION ; HORMONE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200309 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Nagoya Univ, Grad Sch Engn, Chikusa Ku, Furo Cho, Nagoya, Aichi 4648603, Japan; 2.Nagoya Univ, Inst Transformat Biomol WPI ITbM, Chikusa Ku, Furo Cho, Nagoya, Aichi 4648601, Japan; 3.Nagoya Univ, Grad Sch Sci, Chikusa Ku, Furo Cho, Nagoya, Aichi 4648602, Japan; 4.Osaka Prefecture Univ, Grad Sch Life & Environm Sci, Naka Ku, 1-1 Gakuen Cho, Sakai, Osaka 5998531, Japan; 5.Univ Toronto, Dept Cell & Syst Biol, 25 Willcocks St, Toronto, ON M5S 3B2, Canada; 6.Nagoya Univ, JST, CREST, Japan Sci & Technol Agcy, Nagoya, Aichi 4648601, Japan; 7.Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, 46-29 Yoshida Shimo Adachi Cho, Kyoto 6068501, Japan; 8.Oak Ridge Natl Lab, Computat Sci & Engn Div, Oak Ridge, TN 37831 USA; 9.Oak Ridge Natl Lab, Chem Sci Div, Oak Ridge, TN 37831 USA |
推荐引用方式 GB/T 7714 | Uraguchi, Daisuke,Kuwata, Keiko,Hijikata, Yuh,et al. A femtomolar-range suicide germination stimulant for the parasitic plant Striga hermonthica[J]. SCIENCE,2018,362(6420):1301-+. |
APA | Uraguchi, Daisuke.,Kuwata, Keiko.,Hijikata, Yuh.,Yamaguchi, Rie.,Imaizumi, Hanae.,...&Tsuchiya, Yuichiro.(2018).A femtomolar-range suicide germination stimulant for the parasitic plant Striga hermonthica.SCIENCE,362(6420),1301-+. |
MLA | Uraguchi, Daisuke,et al."A femtomolar-range suicide germination stimulant for the parasitic plant Striga hermonthica".SCIENCE 362.6420(2018):1301-+. |
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