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DOI | 10.1126/science.aar7854 |
A DNA methylation reader complex that enhances gene transcription | |
Harris, C. Jake1; Scheibe, Marion2; Wongpalee, Somsakul Pop1,9; Liu, Wanlu1; Cornett, Evan M.3; Vaughan, Robert M.3; Li, Xueqin4; Chen, Wei4; Xue, Yan1; Zhong, Zhenhui1,5; Yen, Linda1; Barshop, William D.6; Rayatpisheh, Shima6,10; Gallego-Bartolome, Javier1; Groth, Martin1,11; Wang, Zonghua5,7; Wohlschlegel, James A.6; Du, Jiamu4; Rothbart, Scott B.3; Butter, Falk2; Jacobsen, Steven E.1,8 | |
2018-12-07 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 362期号:6419页码:1182-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Germany; Peoples R China; Thailand |
英文摘要 | DNA methylation generally functions as a repressive transcriptional signal, but it is also known to activate gene expression. In either case, the downstream factors remain largely unknown. By using comparative interactomics, we isolated proteins in Arabidopsis thaliana that associate with methylated DNA. Two SU(VAR)3-9 homologs, the transcriptional antisilencing factor SUVH1, and SUVH3, were among the methyl reader candidates. SUVH1 and SUVH3 bound methylated DNA in vitro, were associated with euchromatic methylation in vivo, and formed a complex with two DNAJ domain-containing homologs, DNAJ1 and DNAJ2. Ectopic recruitment of DNAJ1 enhanced gene transcription in plants, yeast, and mammals. Thus, the SUVH proteins bind to methylated DNA and recruit the DNAJ proteins to enhance proximal gene expression, thereby counteracting the repressive effects of transposon insertion near genes. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000452506300061 |
WOS关键词 | RNA-POLYMERASE V ; EPIGENETIC ALLELES ; ACTIVATION ; MECHANISM ; DOMAIN ; PLANTS ; DEMETHYLATION ; EXPRESSION ; PROTEINS ; PATTERNS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200248 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Calif Los Angeles, Dept Mol Cell & Dev Biol, Los Angeles, CA 90095 USA; 2.Inst Mol Biol, Quantitat Prote, D-55128 Mainz, Germany; 3.Van Andel Res Inst, Ctr Epigenet, Grand Rapids, MI 49503 USA; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Ctr Plant Stress Biol, Natl Key Lab Plant Mol Genet,CAS Ctr Excellence M, Shanghai 201602, Peoples R China; 5.Fujian Agr & Forestry Univ, State Key Lab Ecol Pest Control Fujian & Taiwan C, Fuzhou 350002, Fujian, Peoples R China; 6.Univ Calif Los Angeles, David Geffen Sch Med, Dept Biol Chem, Los Angeles, CA 90095 USA; 7.Minjiang Univ, Inst Oceanog, Fuzhou 350108, Fujian, Peoples R China; 8.Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90024 USA; 9.Chiang Mai Univ, Dept Microbiol, Fac Med, Chiang Mai 50200, Thailand; 10.Novartis Res Fdn, Genom Inst, 10675 John Jay Hopkins Dr, San Diego, CA 92121 USA; 11.Helmholtz Zentrum Munchen, Inst Biochem Plant Pathol, D-85764 Neuherberg, Germany |
推荐引用方式 GB/T 7714 | Harris, C. Jake,Scheibe, Marion,Wongpalee, Somsakul Pop,et al. A DNA methylation reader complex that enhances gene transcription[J]. SCIENCE,2018,362(6419):1182-+. |
APA | Harris, C. Jake.,Scheibe, Marion.,Wongpalee, Somsakul Pop.,Liu, Wanlu.,Cornett, Evan M..,...&Jacobsen, Steven E..(2018).A DNA methylation reader complex that enhances gene transcription.SCIENCE,362(6419),1182-+. |
MLA | Harris, C. Jake,et al."A DNA methylation reader complex that enhances gene transcription".SCIENCE 362.6419(2018):1182-+. |
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