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DOI | 10.1126/science.aat6768 |
A mechanistic classification of clinical phenotypes in neuroblastoma | |
Ackermann, Sandra1; 39;Sullivan, Roderick J.2 | |
2018-12-07 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 362期号:6419页码:1165-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; Belgium; Pakistan; USA |
英文摘要 | Neuroblastoma is a pediatric tumor of the sympathetic nervous system. Its clinical course ranges from spontaneous tumor regression to fatal progression. To investigate the molecular features of the divergent tumor subtypes, we performed genome sequencing on 416 pretreatment neuroblastomas and assessed telomere maintenance mechanisms in 208 of these tumors. We found that patients whose tumors lacked telomere maintenance mechanisms had an excellent prognosis, whereas the prognosis of patients whose tumors harbored telomere maintenance mechanisms was substantially worse. Survival rates were lowest for neuroblastoma patients whose tumors harbored telomere maintenance mechanisms in combination with RAS and/or p53 pathway mutations. Spontaneous tumor regression occurred both in the presence and absence of these mutations in patients with telomere maintenance-negative tumors. On the basis of these data, we propose a mechanistic classification of neuroblastoma that may benefit the clinical management of patients. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000452687800001 |
WOS关键词 | TELOMERASE ACTIVITY ; RNA-SEQ ; EXPRESSION ; MUTATIONS ; FREQUENT ; MYCN ; REARRANGEMENTS ; INHIBITION ; ACTIVATION ; TUMORS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200246 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Childrens Hosp Cologne, Med Fac, Dept Expt Pediat Oncol, Cologne, Germany; 2.Univ Cologne, Ctr Mol Med Cologne CMMC, Cologne, Germany; 3.Univ Cologne, Med Fac, Dept Translat Genom, Ctr Integrated Oncol Cologne Bonn, Cologne, Germany; 4.Univ Childrens Hosp Cologne, Med Fac, Dept Pediat Oncol & Hematol, Cologne, Germany; 5.Univ Munster, Inst Biostat & Clin Res, Munster, Germany; 6.NEO New Oncol GmbH, Cologne, Germany; 7.German Canc Res Ctr, Div Neuroblastoma Genom B087, Heidelberg, Germany; 8.Hopp Childrens Canc Ctr NCT Heidelberg KiTZ, Heidelberg, Germany; 9.German Canc Res Ctr, Div Pediat Neurooncol, Heidelberg, Germany; 10.Univ Cologne, Cologne Ctr Genom, Cologne, Germany; 11.Univ Cologne, Cologne Excellence Cluster Cellular Stress Respon, Cologne, Germany; 12.Univ Ghent, Ctr Med Genet, Ghent, Belgium; 13.COMSATS Univ Islamabad, IRCBM, Lahore Campus, Lahore, Pakistan; 14.Charite Univ Med Berlin, Dept Pediat Oncol & Hematol, Berlin, Germany; 15.German Canc Consortium DKTK, Heidelberg, Germany; 16.Berlin Inst Hlth, Berlin, Germany; 17.Univ Pittsburgh, Med Ctr, Dept Pathol, Pittsburgh, PA USA; 18.Pathol Univ Med Ctr Schleswig Holstein, Campus Luebeck, Lubeck, Germany; 19.Leibniz Ctr Med & Biosci, Res Ctr Borstel, Borstel, Germany; 20.Univ Hosp Cologne, Dept Diagnost & Intervent Radiol, Cologne, Germany; 21.Univ Cologne, Dept Nucl Med, Cologne, Germany; 22.Univ Duisburg Essen, Univ Hosp Essen, Inst Human Genet, Genome Informat, Essen, Germany; 23.TU Dortmund, Comp Sci, Dortmund, Germany; 24.Univ Cologne, Comp Ctr, Cologne, Germany; 25.Univ Cologne, Dept Informat, Cologne, Germany; 26.Univ Kiel, Dept Pediat Pathol, Kiel Pediat Tumor Registry, Kiel, Germany; 27.Univ Cologne, Dept Pathol, Cologne, Germany; 28.UPCI, Hillman Canc Ctr, Dept Pharmacol & Chem Biol, Pittsburgh, PA USA; 29.German Canc Res Ctr, Heidelberg, Germany; 30.Univ Duisburg Essen, West German Canc Ctr Essen, Dept Med Oncol, Essen, Germany |
推荐引用方式 GB/T 7714 | Ackermann, Sandra,39;Sullivan, Roderick J.. A mechanistic classification of clinical phenotypes in neuroblastoma[J]. SCIENCE,2018,362(6419):1165-+. |
APA | Ackermann, Sandra,&39;Sullivan, Roderick J..(2018).A mechanistic classification of clinical phenotypes in neuroblastoma.SCIENCE,362(6419),1165-+. |
MLA | Ackermann, Sandra,et al."A mechanistic classification of clinical phenotypes in neuroblastoma".SCIENCE 362.6419(2018):1165-+. |
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