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DOI | 10.1126/science.aat2512 |
The paraventricular thalamus is a critical thalamic area for wakefulness | |
Ren, Shuancheng1; Wang, Yaling1; Yue, Faguo1,2; Cheng, Xiaofang1; Dang, Ruozhi1; Qiao, Qicheng1; Sun, Xueqi1; Li, Xin1; Jiang, Qian2; Yao, Jiwei3; Qin, Han3; Wang, Guanzhong1; Liao, Xiang3; Gao, Dong2; Xia, Jianxia1; Zhang, Jun1; Hu, Bo; Yan, Junan3; Wang, Yanjiang4; Xu, Min5; Han, Yunyun6,7; Tang, Xiangdong8; Chen, Xiaowei3; He, Chao1; Hu, Zhian1 | |
2018-10-26 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 362期号:6413页码:429-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
英文摘要 | Clinical observations indicate that the paramedian region of the thalamus is a critical node for controlling wakefulness. However, the specific nucleus and neural circuitry for this function remain unknown. Using in vivo fiber photometry or multichannel electrophysiological recordings in mice, we found that glutamatergic neurons of the paraventricular thalamus (PVT) exhibited high activities during wakefulness. Suppression of PVT neuronal activity caused a reduction in wakefulness, whereas activation of PVT neurons induced a transition from sleep to wakefulness and an acceleration of emergence from general anesthesia. Moreover, our findings indicate that the PVT-nucleus accumbens projections and hypocretin neurons in the lateral hypothalamus to PVT glutamatergic neurons' projections are the effector pathways for wakefulness control. These results demonstrate that the PVT is a key wakefulness-controlling nucleus in the thalamus. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000450441900043 |
WOS关键词 | NUCLEUS ; MIDLINE ; INTRALAMINAR ; PROJECTIONS ; SLEEP ; RAT ; SPECIFICITY ; CIRCUIT |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199931 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Third Mil Med Univ, Dept Physiol, Collaborat Innovat Ctr Brain Sci, Chongqing 400038, Peoples R China; 2.Third Mil Med Univ, Daping Hosp, Dept Sleep & Psychol, Chongqing 400042, Peoples R China; 3.Third Mil Med Univ, Brain Res Ctr, Chongqing 400038, Peoples R China; 4.Third Mil Med Univ, Daping Hosp, Dept Neurol, Chongqing 400042, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Neurosci, Inst Neurosci, Shanghai 200031, Peoples R China; 6.Huazhong Univ Sci & Technol, Sch Basic Med, Dept Neurobiol, Wuhan 430030, Hubei, Peoples R China; 7.Huazhong Univ Sci & Technol, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China; 8.Sichuan Univ, West China Hosp, Sleep Med Ctr,Translat Neurosci Ctr, Lab Anaesthesia & Critical Care Med,Sleep Med Ctr, Chengdu 610041, Sichuan, Peoples R China |
推荐引用方式 GB/T 7714 | Ren, Shuancheng,Wang, Yaling,Yue, Faguo,et al. The paraventricular thalamus is a critical thalamic area for wakefulness[J]. SCIENCE,2018,362(6413):429-+. |
APA | Ren, Shuancheng.,Wang, Yaling.,Yue, Faguo.,Cheng, Xiaofang.,Dang, Ruozhi.,...&Hu, Zhian.(2018).The paraventricular thalamus is a critical thalamic area for wakefulness.SCIENCE,362(6413),429-+. |
MLA | Ren, Shuancheng,et al."The paraventricular thalamus is a critical thalamic area for wakefulness".SCIENCE 362.6413(2018):429-+. |
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