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DOI | 10.1126/science.aau6324 |
PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex | |
Zeng, Wei-Zheng1; Marshall, Kara L.1; Min, Soohong2; Daou, Ihab1; Chapleau, Mark W.3,4; Abboud, Francois M.3; Liberles, Stephen D.2; Patapoutian, Ardem1 | |
2018-10-26 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 362期号:6413页码:464-467 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Activation of stretch-sensitive baroreceptor neurons exerts acute control over heart rate and blood pressure. Although this homeostatic baroreflex has been described for more than 80 years, the molecular identity of baroreceptor mechanosensitivity remains unknown. We discovered that mechanically activated ion channels PIEZO1 and PIEZO2 are together required for baroreception. Genetic ablation of both Piezo1 and Piezo2 in the nodose and petrosal sensory ganglia of mice abolished drug-induced baroreflex and aortic depressor nerve activity. Awake, behaving animals that lack Piezos had labile hypertension and increased blood pressure variability, consistent with phenotypes in baroreceptor-denervated animals and humans with baroreflex failure. Optogenetic activation of Piezo2-positive sensory afferents was sufficient to initiate baroreflex in mice. These findings suggest that PIEZO1 and PIEZO2 are the long-sought baroreceptor mechanosensors critical for acute blood pressure control. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000450441900052 |
WOS关键词 | BAROREFLEX FAILURE ; AUTONOMIC CONTROL ; PROPOSED ROLE ; HEART-RATE ; ARTERIAL ; HYPERTENSION ; DENERVATION ; CHANNEL ; MICE ; VARIABILITY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199921 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Scripps Res Inst, Dorris Neurosci Ctr, Neurosci Dept, Howard Hughes Med Inst, La Jolla, CA 92037 USA; 2.Harvard Med Sch, Dept Cell Biol, Howard Hughes Med Inst, Boston, MA 02115 USA; 3.Univ Iowa, Carver Coll Med, Dept Internal Med & Mol Physiol & Biophys, Abboud Cardiovasc Res Ctr, Iowa City, IA 52242 USA; 4.Vet Affairs Med Ctr, Iowa City, IA 52242 USA |
推荐引用方式 GB/T 7714 | Zeng, Wei-Zheng,Marshall, Kara L.,Min, Soohong,et al. PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex[J]. SCIENCE,2018,362(6413):464-467. |
APA | Zeng, Wei-Zheng.,Marshall, Kara L..,Min, Soohong.,Daou, Ihab.,Chapleau, Mark W..,...&Patapoutian, Ardem.(2018).PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex.SCIENCE,362(6413),464-467. |
MLA | Zeng, Wei-Zheng,et al."PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex".SCIENCE 362.6413(2018):464-467. |
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