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DOI | 10.1126/science.aan8423 |
DNGR-1 in dendritic cells limits tissue damage by dampening neutrophil recruitment | |
del Fresno, Carlos1; Saz-Leal, Paula1; Enamorado, Michel1,6; Wculek, Stefanie K.1; Martinez-Cano, Sarai1; Blanco-Menendez, Noelia1; Schulz, Oliver2; Gallizioli, Mattia3; Miro-Mur, Francesc3; Cano, Eva4; Planas, Anna3,5; Sancho, David1 | |
2018-10-19 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 362期号:6412页码:351-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Spain; England; USA |
英文摘要 | Host injury triggers feedback mechanisms that limit tissue damage. Conventional type 1 dendritic cells (cDC1s) express dendritic cell natural killer lectin group receptor-1 (DNGR-1), encoded by the gene Clec9a, which senses tissue damage and favors cross-presentation of dead-cell material to CD8(+) T cells. Here we find that DNGR-1 additionally reduces hostdamaging inflammatory responses induced by sterile and infectious tissue injury in mice. DNGR-1 deficiency leads to exacerbated caerulein-induced necrotizing pancreatitis and increased pathology during systemic Candida albicans infection without affecting fungal burden. This effect is B and T cell-independent and attributable to increased neutrophilia in DNGR-1-deficient settings. Mechanistically, DNGR-1 engagement activates SHP-1 and inhibits MIP-2 (encoded by Cxcl2) production by cDC1s during Candida infection. This consequently restrains neutrophil recruitment and promotes disease tolerance. Thus, DNGR1-mediated sensing of injury by cDC1s serves as a rheostat for the control of tissue damage, innate immunity, and immunopathology. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000447680100051 |
WOS关键词 | SYSTEMIC CANDIDIASIS ; T-CELLS ; F-ACTIN ; RECEPTOR ; MICE ; INFECTION ; INFLAMMATION ; IMMUNITY ; DECTIN-1 ; ANTIGENS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199883 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.CNIC, Immunobiol Lab, Madrid, Spain; 2.Francis Crick Inst, Immunobiol Lab, London, England; 3.Inst Invest Biomed August Pi i Sunyer IDIBAPS, Barcelona, Spain; 4.Inst Salud Carlos III, Chron Dis Programme CROSADIS, Madrid, Spain; 5.CSIC, IIBB, Dept Brain Ischemia & Neurodegenerat, Barcelona, Spain; 6.NIAID, Mucosal Immunol Sect, Lab Parasit Dis, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA |
推荐引用方式 GB/T 7714 | del Fresno, Carlos,Saz-Leal, Paula,Enamorado, Michel,et al. DNGR-1 in dendritic cells limits tissue damage by dampening neutrophil recruitment[J]. SCIENCE,2018,362(6412):351-+. |
APA | del Fresno, Carlos.,Saz-Leal, Paula.,Enamorado, Michel.,Wculek, Stefanie K..,Martinez-Cano, Sarai.,...&Sancho, David.(2018).DNGR-1 in dendritic cells limits tissue damage by dampening neutrophil recruitment.SCIENCE,362(6412),351-+. |
MLA | del Fresno, Carlos,et al."DNGR-1 in dendritic cells limits tissue damage by dampening neutrophil recruitment".SCIENCE 362.6412(2018):351-+. |
条目包含的文件 | 条目无相关文件。 |
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