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DOI | 10.1126/science.aao6750 |
Aptamer-field-effect transistors overcome Debye length limitations for small-molecule sensing | |
Nakatsuka, Nako1,2; Yang, Kyung-Ae3; Abendroth, John M.1,2; Cheung, Kevin M.1,2; Xu, Xiaobin1,2; Yang, Hongyan4,5; Zhao, Chuanzhen1,2; Zhu, Bowen1,6; Rim, You Seung1,6,9; Yang, Yang1,6; Weiss, Paul S.1,2,6; Stojanovic, Milan N.3,7,8; Andrews, Anne M.1,2,4,5 | |
2018-10-19 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 362期号:6412页码:319-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; South Korea |
英文摘要 | Detection of analytes by means of field-effect transistors bearing ligand-specific receptors is fundamentally limited by the shielding created by the electrical double layer (the "Debye length" limitation). We detected small molecules under physiological high-ionic strength conditions by modifying printed ultrathin metal-oxide field-effect transistor arrays with deoxyribonucleotide aptamers selected to bind their targets adaptively. Target-induced conformational changes of negatively charged aptamer phosphodiester backbones in close proximity to semiconductor channels gated conductance in physiological buffers, resulting in highly sensitive detection. Sensing of charged and electroneutral targets (serotonin, dopamine, glucose, and sphingosine-1-phosphate) was enabled by specifically isolated aptameric stem-loop receptors. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000447680100043 |
WOS关键词 | LIFT-OFF LITHOGRAPHY ; CIRCULAR-DICHROISM ; G-QUADRUPLEX ; BIOSENSORS ; SEROTONIN ; RECOGNITION ; RECEPTORS ; DNA |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199881 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Calif Los Angeles, Calif NanoSyst Inst, Los Angeles, CA 90095 USA; 2.Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA; 3.Columbia Univ, Dept Med, Ctr Innovat Diagnost & Therapeut Approaches, New York, NY 10032 USA; 4.Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA; 5.Univ Calif Los Angeles, Hatos Ctr Neuropharmacol, Los Angeles, CA 90095 USA; 6.Univ Calif Los Angeles, Dept Mat Sci & Engn, Los Angeles, CA 90095 USA; 7.Columbia Univ, Dept Biomed Engn, New York, NY 10032 USA; 8.Columbia Univ, Dept Syst Biol, New York, NY 10032 USA; 9.Sejong Univ, Sch Intelligent Mechatron Engn, Seoul 05006, South Korea |
推荐引用方式 GB/T 7714 | Nakatsuka, Nako,Yang, Kyung-Ae,Abendroth, John M.,et al. Aptamer-field-effect transistors overcome Debye length limitations for small-molecule sensing[J]. SCIENCE,2018,362(6412):319-+. |
APA | Nakatsuka, Nako.,Yang, Kyung-Ae.,Abendroth, John M..,Cheung, Kevin M..,Xu, Xiaobin.,...&Andrews, Anne M..(2018).Aptamer-field-effect transistors overcome Debye length limitations for small-molecule sensing.SCIENCE,362(6412),319-+. |
MLA | Nakatsuka, Nako,et al."Aptamer-field-effect transistors overcome Debye length limitations for small-molecule sensing".SCIENCE 362.6412(2018):319-+. |
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